Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery

Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery

Inclusion Criteria:

• Patients undergoing gastrointestinal tumor surgery
• American Society of Anesthesiologists（ASA）≤Ⅲ

Exclusion Criteria:

• History of severe adverse reactions to oral acetaminophen
• Dysfunction of heart, liver, kidney and other important organs
• History of chronic pain
• Oral non-steroidal or opioid drugs
• Patients who do not accept clinical trials