Study on Clinical Value of Vitamin D in Recurrent Spontaneous Abortion

The Role and Mechanism of Vitamin D in Recurrent Spontaneous Abortion Based on Maternal Fetal Interface Immune Tolerance

The observational study is to compare vitamin D deficiency and related indicators among different spontaneous abortions in describe female reproductive health.The main question aim to answer is: the possible pathogenesis of recurrent spontaneous abortion caused by vitamin D.

Participants, who visit the RSA specialty clinic, will provide medical history information, regularly exam based on the condition, following up on pregnancy status.Participants will be asked to supply vitamin D preparation and do moderate exercise outdoors, comparing the effect after treatment.

Examinations include uterine artery resistance parameter S/D, some embryonic chromosomes tested voluntarily, plasma VD content and the level of anticardiolipin antibody.

Inclusion Criteria:

• Clinical diagnosis of patients without spontaneous abortion;
• Clinical diagnosis of patients with a spontaneous abortion;
• Clinical diagnosis of patients with recurrent pontaneous abortions;

Exclusion Criteria:

• Patients with chromosomal abnormalities in RSA couples, such as balanced translocation;
• Patients who take VD preparations or related VD supplements within 3 months before treatment;
• Patients with a combination of certain malignant tumors and severe mental illness.