This study aims to evaluate the feasibility and safety of Cold snare polypectomy for removing 5-9mm small intestinal polyps in patients with Peutz-Jeghers Syndrome (PJS),in order to provide some reference for clinical strategy of endoscopic treatment of small intestinal polyps in PJS patients, and may prolong the follow-up period of PJS patients Intervals.

Inclusion Criteria:

• Age 8-60, male or female.
• Diagnosed with Peutz-Jeghers Syndrome
• Undergo enteroscopy for small bowel polypectomy.

Exclusion Criteria:

• Absence of at least one study polyp (5-9mm stubby pedicle, wide pedicle and sessile small bowel polyps);
• Be evaluated during enteroscopy for requiring surgical intervention (such as endoscopically difficult to handle giant polyps, intussusception, etc.)；
• With more than 50 polyps ≥1cm found in this enteroscopy examination;
• The polyp has been confirmed to be malignant by pathology, or highly suspicious of malignant transformation under endoscopy;
• Receiving anticoagulant therapy during this treatment;
• Unable or unwilling to provide informed consent.