Coordination is essential for the performance of most daily motor activities. Coordination problems are common in MS patients. One of the most commonly reported symptoms is dysmetria (limb ataxia). Ataxia is thought to occur in about 80% of MS patients. It leads to limitations in daily life activities. Aim of Study: to investigate the effect of life kinetik training on lower limb coordination in MS patients with ataxia.

Methods: Thirty remitting relapsing Multiple Sclerosis (RRMS) patients from both sexes with ataxic symptoms, will be recruited from multiple sclerosis specialized clinic in the Neurology department, Faculty of Medicine, Cairo University with EDSS score will be ranged from 2 to 4 and SARA score will be ranged from 1 to 10. Lower Extremity Motor Coordination Test (LEMOCOT) will be used to assess lower limb motor coordination. They will be randomly assigned into two equal groups; control group (GI) will receive selected physical therapy program and study group (GII) will receive same program of (GI) in addition to life kinetik training.

Inclusion Criteria:

• MS from both sexes
• Patients' age will be ranged from 20 to 45 years
• Expanded disability scale (EDSS) score ranging from "two" to "four"

Exclusion Criteria:

• Patients with Ataxia caused by other cause rather than MS
• Patients with other neurological disease or orthopedic deformities may affect movement
• Patients with cardiovascular and pulmonary diseases that make exercise unsafe
• Patients with cognitive impairment or psychiatric disorders