The Regulatory Role of Immune Response in Oral Lichen Planus

The Regulatory Role of Immune Response in Oral Lichen Planus With Mental Disorders

Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it. In vitro, previous studies have shown that oral mucosal mesenchymal stem cell cells (MSCs) can secrete Ido, which is involved in the pathogenesis of OLP. It has been proved that mental disorders such as depression and anxiety play an important role in the pathogenesis and treatment of OLP. Mental stress factors can cause abnormal changes of inflammatory factors, leading to immune dysfunction, which is also one of the main causes of OLP. In this study, we integrated the advantages of stomatology, psychiatry, neurobiology and traditional Chinese medicine, focused on the clinical problems of mental disorders with oral mucosal comorbidity, and assessed the depressive and anxiety status of OLP patients, so as to improve the therapeutic effect of OLP.

Inclusion Criteria:

• patients with oral lichen planus
• male or female patients older than 18 years of age
• patients willing to participate with signed informed consent.

Exclusion Criteria:

• pregnant or lactating
• had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors
• were unwilling to participate in the experiment.