The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation

The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation

The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.

Disseminated intravascular coagulation (DIC) is a life-threatening condition with high mortality, necessitating timely and accurate diagnosis for effective management. However, current diagnostic systems can not recognize DIC at its reversible phase, causing suboptimal treatment outcomes. Consequently, the current diagnostic criteria for DIC lacks earlier laboratory indicators. Therefore, the investigators aimed to assess the diagnostic potential of selected hemostatic biomarkers, including thrombin-antithrombin complex (TAT), soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (tPAI-C), α2-plasmin inhibitor plasmin complex (PIC) and anti-thrombin III (ATIII), in evaluating DIC, allowing for proactive diagnosis before the disease progresses into its irreversible phase.

Inclusion Criteria:

• 18 years old, non-perinatal period, a hospitalization length of≥3 days.

Exclusion Criteria:

• primary hematologic diseases, decompensated liver cirrhosis, chemotherapy history.