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compare the time of second hypotension after administration of three different doses of ephedrine 5,10,15 mg
In cesarean section, under subarachnoid block the most common complication is hypotension with a reported incidence greater than 80%. Hypotension may occur even after left uterine displacement and preloading with crystalloid. The severity of hypotension depends on the degree of aortocaval compression syndrome, the amount of crystalloid preloading, doses of local anesthetic drugs administered. The most effective treatment of hypotension associated with cesarean section under subarachnoid block is the administration of vasopressor drugs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group-I | Active Comparator | received 5mg of Ephedrine after the first hypotension [ Base line time or starting point is first hypotension] |
|
| Group-II | Active Comparator | received 10mg of Ephedrine after the first hypotension [ Base line time or starting point is first hypotension] |
|
| Group-III | Active Comparator | 15mg bolus dose of ephedrine IV after the first hypotension [ Base line time or starting point is first hypotension] |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ephedrine 5mg | Drug | Patients received 5mg bolus dose of ephedrine Intravenous after the first hypotension [ Base line time or starting point is first hypotension] |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival analysis or time until an event occurs | The study time is a30 minute and blood pressure is measured automatically non invasive at 3-minute intervals. If systolic blood pressure decreased more than 20% from the baseline(Event) | Intraoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Starting point or Base line time | Starting point or Base line time is a first hypotension | Intraoperatively |
| Survival time | Free of event(No hypotension) at any time after base line |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan University | Aswān | 81511 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
after the end of study for one year.
The data will be available upon a reasonable request from the corresponding author
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| ID | Term |
|---|---|
| D004809 | Ephedrine |
| ID | Term |
|---|---|
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Ephedrine 10mg | Drug | Patients received 10mg bolus dose of ephedrine Intravenous after the first hypotension [ Base line time or starting point is first hypotension] |
|
| Ephedrine 15mg | Drug | Patients received 15mg bolus dose of ephedrine Intravenous after the first hypotension [ Base line time or starting point is first hypotension] |
|
| Intraoperatively |
| D020005 |
| Propanols |
| D000588 | Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |