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Treatment of disorders such as gastrointestinal tract (GI) perforation, ischemia and obstruction often require acute high-risk abdominal surgery, which is associated with a high risk of complications such as myocardial injury after non-cardiac surgery (MINS) and mortality. The majority of patients with MINS will not experience any symptoms, and thus MINS remains undetected without routine troponin measurements.
The investigators hypothesized that implementing surveillance with troponin I as a standard care might be useful as risk stratification, and that increased surveillance, examinations, and subsequent individually based medical interventions, might improve the outcomes for patients with MINS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients not undergoing troponin I surveillance | Patients undergoing acute high-risk abdominal surgery during the period February 1, 2018, to February 28, 2019. No troponin I measurements were made. | ||
| Patients undergoing troponin I surveillance | Patients undergoing acute high-risk abdominal surgery during the period March 1, 2019, to February 28, 2021 as well as postoperative troponin I surveillance . |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Troponin I | Diagnostic Test | Troponin I were measured 6-12 hours postoperatively and on each of the succeeding four postoperative days for patients operated March 1, 2019, to February 28, 2021. Patients with increased troponin I levels were assessed regarding symptoms of myocardial ischaemia including electrocardiography. Each patient was individually assessed, and relevant treatment and follow-up were planned in collaboration between surgeons, cardiologists, and anaesthesiologists. |
| Measure | Description | Time Frame |
|---|---|---|
| compare the mortality rate before and after implementing troponin I surveillance | compare the 30-, 90-, and 365-day mortality rate after acute hugh-risk abdominal surgery in patients undergoing postoperative troponin I surveillance and subsequent intervention with a historical group of patients not undergoing troponin I surveillance. | 30-, 90-, and 365-day |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing acute high-risk abdominal surgery at Copenhagen University Hospital - North Zealand, Denmark during the period February 1, 2018, to February 28, 2021.
For patients undergoing acute high-risk abdominal surgery on more than occasion during the period of observation, only the first case of surgery was included.
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| Name | Affiliation | Role |
|---|---|---|
| Claus Anders TB Bertelsen, PhD, MD | Copenhagen University Hospital - North Zealand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Copenhagen University Hospital - North Zealand | Hillerød | 3400 | Denmark |
IPD can be shared at request.
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| ID | Term |
|---|---|
| D000006 | Abdomen, Acute |
| ID | Term |
|---|---|
| D015746 | Abdominal Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D012817 | Signs and Symptoms, Digestive |