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| Name | Class |
|---|---|
| BioVendor LM | UNKNOWN |
| Oncology Center Medicon | UNKNOWN |
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Early detection and thus rapid therapy of cardiotoxicity related to chemotherapy are essential for restoring cardiovascular function. The complete recovery of the cardiovascular system decreases with time to identify the presence of cardiotoxic damage. The project aims to define new biomarkers for the early detection of cardiotoxicity in patients treated with chemotherapy.
The most effective approach to minimizing the consequences of cardiotoxicity of oncological treatment is its early identification, adjustment of oncological treatment (change of procedure, dose, drugs), and immediate initiation of cardiovascular therapy. However, the current standard for monitoring the cardiovascular system in cancer patients identifies cardiotoxicity only if functional impairment has already occurred, which precludes any chance of effective prevention. The aim of the project is to identify new biomarkers for the early detection of the cardiotoxic effect of chemotherapy in women with breast cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Women with breast cancer treated with chemotherapeutics without signs of cardiotoxicity |
| ||
| Women with breast cancer treated with chemotherapeutics with signs of cardiotoxicity |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Diagnostic Test | Blood sample collection for mRNA determination |
|
| Measure | Description | Time Frame |
|---|---|---|
| Early detection of the cardiotoxic effect of chemotherapy using new biomarkers | Echocardiography and MRI detection of cardiotoxic effect of chemotherapy - dysfunction of left ventricle, arrythmias, hypertension | one year follow-up. |
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Inclusion Criteria:
Exclusion Criteria:
Breast cancer chemotherapy population
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Women with breast cancer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Robert Petr, MD. | Contact | +420 233 336 334 | robert.petr81@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiology Prague Ltd | Recruiting | Prague | 10100 | Czechia |
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| ID | Term |
|---|---|
| D066126 | Cardiotoxicity |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Echocardiography | Diagnostic Test | Echocardiography for detection of ventricular dysfunction |
|
| Cardio MRI | Diagnostic Test | MRI for early detection of myocardial impairment caused by chemotherapy |
|
| 24-hours monitoring of ECG | Diagnostic Test | Diagnostic test for detection of arrhythmias as a consequence of cardiotoxicity |
|
| 24 hours monitoring of BP | Diagnostic Test | Diagnostic test for detection of hypertension as a consequence of cardiotoxicity |
|
| Oncology Center Medicon | Recruiting | Prague | Czechia |
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
| D064419 | Chemically-Induced Disorders |
| D011832 | Radiation Injuries |
| D014947 | Wounds and Injuries |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |