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| ID | Type | Description | Link |
|---|---|---|---|
| SGS09/LF/2022 | Other Grant/Funding Number | University of Ostrava |
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This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality. The aim was to compare hydratation parameters measured by BIVA: OHY, Extracellular Water (ECW) / Total Body Wate (TBW) and quadrant, vector length, phase angle (PA) with cumulative fluid balance (CFB) recording (input-output) in their ability in predicting mortality as the abilities of the prognostic markers PA (BIVA), Acute Physiology and Chronic Health Evaluation II (APACHE II - score) and presepsin (serum Cluster of Differentiation (CD) 14-ST). The investigators also compared BIVA nutritional indicators (SMM, fat) with BMI and laboratory parameters (albumin, prealbumin and C-reactive protein (CRP) inflammation parameters) in the prediction of mortality. An important goal was to evaluate the usability of the BIVA method in critically ill patients on extracorporeal circulation, to compare the impedance data of the extracorporeal membrane oxygenation (ECMO) and non-ECMO groups.
Hyperhydration has a detrimental effect on mortality risk and morbidity, increases the risk of acute kidney failure, the need of renal replacement therapy (RRT), worsens recovery of renal functions and worsens lung injury (ALI), infectious complications, and causes prolonged artificial pulmonary ventilation (APV), the length of stay on Intensive care unit (ICU), and impairs wound healing.
Real-time assessment of fluid status and management of fluid administration in critically ill patients is challenging. Echocardiography can rapidly identify hemodynamic phenotypes, but it is rather intermittent than continuous methods and requires experienced and trained staff. Semi-invasive methods, based on stroke volume monitoring as the area under the arterial curve and variability of stroke volume variation (SVV) evaluate intravascular volume. However, these methods lack information about the interstitial fluid, part of extracellular water (ECW), or intracellular fluid water (ICW). This problem is partially solved by transpulmonary thermodilution with extravascular lung water (EVLW) measurement and lung ultrasound. Calculating the cumulative balance (CBF) is imprecise, especially in the area of fluid output for insensible losses or third-space fluid losses. Even more imprecise is the clinical assessment of peripheral edema and blood flow. And gold standard deuterium dilution methods for total body water (TBW) are not usable in daily practice in the ICU settings.
In addition to hyperhydration, the rapid loss of muscle tissue in critically ill patients has a negative impact on the course of the disease. Polyneuromyopathy affects up to 40 % of critically ill patients, patients in a severe catabolic state with an activated systemic inflammatory response (SIRS), with corticosteroid therapy, and immobilized on long-term artificial lung ventilation are at risk. Monitoring lean body mass, especially skeletal muscle mass (SMM), is still difficult. Anthropometric measurements and ultrasound measurements of the quadriceps muscles are not ideal because they are time-consuming and require well-trained staff. Some laboratory parameters such as albumin are likely to be influenced by inflammation (CRP), and hydration. Dual-energy X-ray absorptiometers (DEXA) using two different wavelengths of low-intensity X-rays give a relatively accurate picture of bone mass and soft tissues (fat-free mass, active mass, fat). However, repeated X-ray examination in immobilized critically ill patients is not the method of choice.
Bioelectrical impedance vector analysis (BIVA) is a simple, rapid, and noninvasive bedside technique, based on the principle that the flow of altering electrical current through a particular tissue differs depending on the content of water and electrolytes. It is thus able to measure body composition as skeletal muscle mass (SMM), and body cell mass (BCM), including total body water and extracellular water. And with the use of 50 frequencies of bioimpedance spectroscopy (BIS), it is possible to distinguish TBW, ECW, and from their different intracellular water, because only electric current with a frequency higher than 100 Hertz (Hz) passes through the cell membrane. However, the technique cannot distinguish between intravascular and interstitial volumes in the extracellular compartment. According to a number of studies, the results of bioimpedance parameters of body composition are comparable to DEXA. However, BIA overestimates the representation of muscle. An important parameter is the phase angle (PA), which detects a time delay of the passage of current through the cell membrane, i.e., a phase shift between the sinusoidal voltage and current waveforms. PA reflects BCM and serves as an important prognostic factor, with a normal value of 4-15°.
Of the laboratory markers, presepsin (PSEP) has prognostic significance. Presepsin, soluble Cluster of differentiation 14 (sCD14), is a glycoprotein expressed in the membranes of monocytes and macrophages in response to pathogen-associated molecular patterns (PAMPs: lipopolysaccharide, peptidoglycan) part of the bacterial wall or to other damage to cells - damage-associated molecular patterns (DAMPs). An interesting finding is its prognostic role, i.e. higher values in non-surviving patients, evaluated by a number of studies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group of Patients who Survived (S) | The group is defined by the number of patients who survived. |
| |
| Group of Patients who Died (D) | The group is defined by the number of patients who died. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bioelectrical impedance vector analysis (BIVA) | Device | BIVA is a simple, rapid, and noninvasive method, based on the principle that the flow of altering electrical current through a particular tissue differs depending on the content of water and electrolytes, used for monitoring hydratation and nutritional status in critically ill patients. |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass (physique) - Bioelectrical impedance analysis (BIA) | Bioelectrical impedance analysis (BIA) comparison of skeletal muscle mass, body fat and body water (expressed in %) in patients hospitalized in the ICU. | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Body Mass (physique) - Phase Angle (PA) | Assessment of the Phase angle (expressed in degrees) as a part of BIA in patients hospitalized in the ICU. | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Body Mass (physique) - BIVA vector analysis (Cole Cole graf) | Assessment of the BIVA vector analysis (Cole Cole graf, expressed as a optimal curve dependence of resistance on reactance always at a specific frequency, divided into quadrants) in patients hospitalized in the ICU. | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Measure | Description | Time Frame |
|---|---|---|
| Indicators of nutritional status (albumin, prealbumin) | Assesment of indicators of nutritional status (albumin, prealbumin in g/l) in serum of patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Measure | Description | Time Frame |
|---|---|---|
| Total body water (TBW) | Total body water measurements (in %) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Extracellular water (ECW) |
Inclusion Criteria:
Exclusion Criteria:
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Critically ill adult patients admitted to 24 beds ICU of the University Hospital with the development of ARDS and the assumption of at least 7 days of artificial lung ventilation (medical, trauma, surgical patients) at the time of admission to the ICU.
Informed consent was obtained from the person legally responsible for the patient.
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| Name | Affiliation | Role |
|---|---|---|
| Marcela Káňová, MD, Ph.D. | University Hospital Ostrava | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Ostrava | Ostrava | Czech Republic | 70852 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30926137 | Background | Vincent JL. Fluid management in the critically ill. Kidney Int. 2019 Jul;96(1):52-57. doi: 10.1016/j.kint.2018.11.047. Epub 2019 Mar 4. | |
| 18533029 | Background | Payen D, de Pont AC, Sakr Y, Spies C, Reinhart K, Vincent JL; Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care. 2008;12(3):R74. doi: 10.1186/cc6916. Epub 2008 Jun 4. |
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There is no plan to share individual participant data with other researchers.
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Full blood and urine
|
| Blood and urine analysis | Diagnostic Test | For regular measurement in 2-3 terms, depending on the length of hospitalization (the first measurement took place within 48 hours of admission, followed one week after admission and the last before transport from the ICU): laboratory indicators of nutritional status will also be taken (albumin, prealbumin, creatinine), inflammation (C-reactive protein, presepsin) and 25-hydroxyvitamin D level. |
|
| cumulative water balance | Diagnostic Test | Cumulative balance is the sum of daily fluid balances during hospitalization. |
|
| Indicator of inflammation (CRP) |
Assesment of indicator of inflammation (C-reactive protein in mg/L) in serum of patients admitted to Intensive Care Unit (ICU). |
| The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Indicator of inflammation - presepsin (PSEP) | Assesment of indicator of inflammation measurements (presepsin in ng/L) in serum of patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
Extracellular water measurements (in %) in patients admitted to Intensive Care Unit (ICU).
| The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Intracellular water (ICW) | Intracellular water measurements (in %) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Overhydration (OHY) | Overhydration measurements (in %) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Ratio ECW/TBW | Ratio ECW/TBW measurements (in %) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Active body mass index (ATH) | Active body mass index measurements (in kg/m2) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Body mass index (BMI) | Body mass index measurements (in kg/m2) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Body fat mass index (BFMI) | Body fat mass index measurements (in kg/m2) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Fat-free mass index (FFMI) | Fat-free mass index measurements (in kg/m2) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Skeletal muscle mass (SMM) | Skeletal muscle mass measurements (in kg) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Body cell mass (BCM) | Body cell mass measurements (in kg) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Basal metabolic rate (BMR) | Basal metabolic rate measurements (in kcal) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Nutric index (NI) | Nutric index measurements (in %) in patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Prediction marker (PM) | Prediction marker measurements in patients admitted to Intensive Care Unit (ICU). The mark value under 0,75 indicates normal condition, value over 0,86 means critical condition. | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Indicators of nutritional status (creatinine) | Indicators of nutritional status measurements (creatinine in µmol/L) in serum of patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Level of 25-hydroxyvitamin D | Level of 25-hydroxyvitamin D measurements (in nmol/L) in serum of patients admitted to Intensive Care Unit (ICU). | The first within 48 hours of admission, the second one week after admission and third before transport from the ICU |
| Cumulative fluid balance (CFB) | Cumulative fluid balance daily measurements (in ml) in patients admitted to Intensive Care Unit (ICU). | Every 24 hours until patient´s transport from the ICU |
| Measurement of energy income | Measurement of daily energy income (in kcals) in patients admitted to Intensive Care Unit (ICU). | Every 24 hours until patient´s transport from the ICU |
| Measurement of protein income | Measurement of daily protein income (in g) in patients admitted to Intensive Care Unit (ICU). | Every 24 hours until patient´s transport from the ICU |
| Assessment of the presence of delirium (CAM-ICU test) | The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) is a simple and short test that enables continuous monitoring of the patients in conditions of ICU (measured as positive/negative). | Every 24 hours until patient´s transport from the ICU |
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| 18926440 | Background | Parrinello G, Paterna S, Di Pasquale P, Torres D, Fatta A, Mezzero M, Scaglione R, Licata G. The usefulness of bioelectrical impedance analysis in differentiating dyspnea due to decompensated heart failure. J Card Fail. 2008 Oct;14(8):676-86. doi: 10.1016/j.cardfail.2008.04.005. Epub 2008 Jun 6. |
| 25959843 | Background | Genot N, Mewton N, Bresson D, Zouaghi O, Francois L, Delwarde B, Kirkorian G, Bonnefoy-Cudraz E. Bioelectrical impedance analysis for heart failure diagnosis in the ED. Am J Emerg Med. 2015 Aug;33(8):1025-9. doi: 10.1016/j.ajem.2015.04.021. Epub 2015 Apr 20. |
| 27396536 | Background | Gil Martinez P, Mesado Martinez D, Curbelo Garcia J, Cadinanos Loidi J. Amino-terminal pro-B-type natriuretic peptide, inferior vena cava ultrasound, and biolectrical impedance analysis for the diagnosis of acute decompensated CHF. Am J Emerg Med. 2016 Sep;34(9):1817-22. doi: 10.1016/j.ajem.2016.06.043. Epub 2016 Jun 14. |
| 24477201 | Background | Di Somma S, Lalle I, Magrini L, Russo V, Navarin S, Castello L, Avanzi GC, Di Stasio E, Maisel A. Additive diagnostic and prognostic value of bioelectrical impedance vector analysis (BIVA) to brain natriuretic peptide 'grey-zone' in patients with acute heart failure in the emergency department. Eur Heart J Acute Cardiovasc Care. 2014 Jun;3(2):167-75. doi: 10.1177/2048872614521756. Epub 2014 Jan 29. |
| 24887300 | Background | Dabrowski W, Kotlinska-Hasiec E, Schneditz D, Zaluska W, Rzecki Z, De Keulenaer B, Malbrain ML. Continuous veno-venous hemofiltration to adjust fluid volume excess in septic shock patients reduces intra-abdominal pressure. Clin Nephrol. 2014 Jul;82(1):41-50. doi: 10.5414/CN108015. |
| 25432556 | Background | Malbrain ML, Marik PE, Witters I, Cordemans C, Kirkpatrick AW, Roberts DJ, Van Regenmortel N. Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice. Anaesthesiol Intensive Ther. 2014 Nov-Dec;46(5):361-80. doi: 10.5603/AIT.2014.0060. |
| 31338808 | Background | Slobod D, Yao H, Mardini J, Natkaniec J, Correa JA, Jayaraman D, Weber CL. Bioimpedance-measured volume overload predicts longer duration of mechanical ventilation in intensive care unit patients. Can J Anaesth. 2019 Dec;66(12):1458-1463. doi: 10.1007/s12630-019-01450-4. Epub 2019 Jul 23. |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D012131 | Respiratory Insufficiency |
| D014869 | Water Intoxication |
| D000860 | Hypoxia |
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D012769 | Shock |
Not provided
Not provided
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D016482 | Urinalysis |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D019963 | Clinical Chemistry Tests |
| D003950 | Diagnostic Techniques, Urological |
Not provided
Not provided