Could Apnea Induce Hypoalgesia?

Could Apnea Induce Hypoalgesia? An Explorative Randomized Controlled Trial

A randomized controlled trial (RCT) in healthy subjects will be conducted with the following aims: (1) Explore the effect of low pulmonary volume dynamic apnoea bouts on Pressure Pain Threshold (PPT) and conditioned pain modulation (CPM); (2) analyse whether CPM response correlates with apnoea induced hypoalgesia; (3) examine the association between apnoea bouts, Rate of Perceived Exertion, hypoxemia and Heart Rate changes in PPT.

A randomized controlled trial (RCT) in healthy subjects will be conducted with the following aims: (1) Explore the effect of low pulmonary volume dynamic apnoea bouts on Pressure Pain Threshold (PPT) and conditioned pain modulation (CPM); (2) analyse whether CPM response correlates with apnoea induced hypoalgesia; (3) examine the association between apnoea bouts Rate of Perceived Exertion, hypoxemia and Heart Rate changes in PPT

Inclusion Criteria:

• Healthy participants
• 18-30 years
• Currently pain-free
• Basal SpO2 ≥95%

Exclusion Criteria:

• Diabetes diagnosis
• Hypertension or hypotension diagnosis
• Pharmacological treatment
• Frequent pain during last month
• Drug consumption
• Self-harming behaviours
• Pregnant or potentially pregnant
• Cardiac or respiratory pathology
• Splenectomy or spleen disease
• Having performed moderate or high intensity physical activity 24 hours prior to the study
• Not having slept the previous night
• Alcohol intake 24 hours prior to study.