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| Name | Class |
|---|---|
| University of Salerno | OTHER |
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Various studies have shown that the milk of a preterm infant differs from that of a term infant in the composition of micronutrients, vitamins, macronutrients, carbohydrates and proteins. The study of lipidomic is of particular interest because the role of fatty acids is known both as essential constituents of cell membranes and as molecules actively involved in energy metabolism. The study of human milk would offer the advantage of offering the best type of nutrition for the newborn at each specific period of life, in the event of a lack of mother's milk.
Mother's milk is the best food for the newborn as it is the only one capable of providing species-specific nutrition, guaranteeing everything necessary for the growth and maturation of a child. Mother's milk has the property of satisfying metabolic needs by changes in the composition of nutrients, which are different at each stage of life. Various studies have shown that the milk of a preterm infant differs from that of a term infant in the composition of micronutrients, such as vitamins, macronutrients, carbohydrates and proteins. The metabolomic study of human milk would offer the advantage of offering the best type of nutrition for the newborn at each specific period of life, in the event of a lack of mother's milk. This is particularly important in a Neonatal Intensive Care Unit, where it is essential to ensure timely adequate enteral nutrition. This is possible if a bank of donated human milk is available. The study of lipidomics is of particular interest, as the role of fatty acids is known both as essential constituents of cell membranes and as molecules actively involved in energy metabolism. Therefore, the benefit deriving from an adequate dietary intake in a constantly evolving organism such as that of a newborn is extremely important.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Women < 32 weeks of gestational age | Women that delivered before 32 weeks of gestational age |
| |
| Women between 32 and 36,6 weeks of gestational age | Women that delivered between 32 and 36,6 weeks of gestational age |
| |
| Women > 37 weeks of gestational age | Women that delivered after 37 weeks of gestational age |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breastfeeding | Other | Mothers will breastfeed their newborns |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of α-Linoleic acid (µg/mL) in human milk | 7 days after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Eicosapentaenoic acid (µg/mL) in human milk | 7 days after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Docosahexaenoic acid (µg/mL) in human milk | 7 days after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Arachidonic acid (µg/mL) in human milk | 7 days after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Linoleic acid (µg/mL) in human milk | 7 days after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of α-Linoleic acid (µg/mL) in human milk | 1 month after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk |
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Inclusion Criteria:
Exclusion Criteria:
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They were enrolled mothers that delivered at Buon Consiglio Fatebenefratelli Hospital, Napoli
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| Name | Affiliation | Role |
|---|---|---|
| Giuseppe De Bernardo, MD | Ospedale Buon Consiglio Fatebenefratelli | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pharmacy, University of Salerno | Salerno | Naples | 84084 | Italy | ||
| Department of Woman and Child, Buon Consiglio Fatebenefratelli Hospital |
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| ID | Term |
|---|---|
| D061186 | Breast Milk Expression |
| ID | Term |
|---|---|
| D001942 | Breast Feeding |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D007774 | Lactation |
| ID | Term |
|---|---|
| D055703 | Reproductive Physiological Phenomena |
| D012101 | Reproductive and Urinary Physiological Phenomena |
| D049590 | Postpartum Period |
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To assess the concentrations of Eicosapentaenoic acid (µg/mL) in human milk |
| 1 month after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Docosahexaenoic acid (µg/mL) in human milk | 1 month after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Arachidonic acid (µg/mL) in human milk | 1 month after delivery |
| Quantification of essential long-chain polyunsaturated fatty acids in human milk | To assess the concentrations of Linoleic acid (µg/mL) in human milk | 1 month after delivery |
| Naples |
| Napoli |
| 80123 |
| Italy |