Effectiveness of Enoxolone on Oral Conditions of Patients With Periodontal Surgery

Effectiveness of Enoxolone on Oral Conditions of Patients With Periodontal Surgery

Abstract Aim:The Enoxolone (18β-glycyrrhetinic acid; BGA) is a bioactive compound in licorice that exhibits potential anti-ulcer, anti-inflammatory, and anti-microbial activities, relieve oral ulcers, pain, improve gingivitis and dental plaque from past relevant experimental studies,but few clinical trials have evaluated its clinical effectiveness. Therefore, the purpose of this study is to evaluate the effectiveness of Enoxolone on oral conditions of patients with periodontal surgery. Methods:This study is a randomized controlled trial. Patients with severe chronic periodontitis who needed to accept periodontal surgery were randomly assigned to two groups, the experimental group was Enoxolone toothpaste, and the control group for Sensodyne toothpaste. After the operation, toothpaste was used three times a day to clean the mouth for 12 weeks . Clinical evaluation was using the patient-reported pain score, painkillers, wound healing index (complete epithelization and color matching score), periodontal pocket depth, gingiva index, plaque index and were recorded before operation and 1st, 2nd, 3rd, 4th, 8th, 12th week after surgery. Data set performs repeated-measures for the change in mean differences by using the two-tailed independent t tests and generalized linear model.

Enoxolone is a toothpaste containing 18β-glycyrrhetinic acid (BGA). In this study, the experimental group used Enoxolone toothpaste, and the control group did not contain BGA toothpaste (Sensodyne), which is used for oral cleaning of patients after periodontal disease surgery. The absorption rate is very low, and it will not cause any interaction with western medicine.

Inclusion Criteria:

• Those who are over 20 years old.
• Those whose health or systemic diseases are well controlled.
• Those with severe chronic periodontitis who need to perform periodontal surgery after being diagnosed by a doctor.
• Subjects who are willing to accept this study.

Exclusion Criteria:

• Allergy to licorice.
• Pregnancy or breastfeeding.
• Periodontal surgery completed at the same site within 6 months.
• Severe bone loss in the apical tissue of the surgical site (including poor prognosis).
• Clinical signs of infection, including fistula, suppuration, fever, severe pain and site swelling.
• Platelets less than 50,000.