This study aimed to evaluate the feasibility and effectiveness of a nurse-led multidisciplinary precision care in early cardiac rehabilitation of patients with chronic heart failure, and further to promote the application of nurse-led multidisciplinary precision care.

Enrolled patients were randomly divided as 1:1 ratio to experimental group and control group, while experimental group received nurse-led multidisciplinary precision care and the control group received standard care according to guidelines. The primary and secondary outcomes were evaluated and analyzed.

Inclusion Criteria:

• Aged from 18 to 80 years;
• Conscious, with normal cognitive function and being communicable;
• NYHA heart function class II-IV;
• Patients met the diagnostic criteria of the clinical guidelines for the diagnosis and treatment of heart failure and were diagnosed with chronic heart failure;
• Informed consent was obtained.

Exclusion Criteria:

• Patients with congenital heart disease, cardiac shock, or persistent hypotension;
• Patients with severe liver and kidney dysfunction, moderate to severe anemia or coagulation disorders, and other serious systemic complications;
• Patients with a history of mental illness, a state of severe anxiety or depression, cognitive or communication impairments, and inability to communicate and respond to investigations;
• Patients have been involved in other research that would interfere with this study;
• Patients who declined cardiac rehabilitation and signed informed consent.