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The goal of the study was to identify the effect of CYP2C9 gene polymorphism in the Pakistani population. The main question it aims to answer were:
The goal of this study was to identify the effect of CYP2C9*3 gene polymorphism in the Pakistani population, due to the high prevalence of this variant in the Pakistani Population
The main question it aims to answer were:
The blood samples of the participants were taken and further genotyping was performed using conventional tetraARMS PCR. The results were visualized by gel electrophoresis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ibuprofen | Ibuprofen 400mg TDS |
| |
| Placebo | Tab Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ibuprofen 400 mg | Drug | Ibuprofen 400 mg TDS |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analogue Scale | A Visual Analogue Scale (VAS) is one of the self-administered pain rating scales, to measure pain intensity. The pain was interpreted as no pain (0-4 mm), mild pain(5-44 mm), moderate pain (45-74 mm), and severe pain (75-100 mm). | three days |
| Measure | Description | Time Frame |
|---|---|---|
| General Assessment of Side Effects scale | The self-rating scale General Assessment of Side Effects (GASE), is about the most frequent side effects in clinical trials of different drugs. Every symptom (dyspepsia, nausea, diarrhea) had to be answered twice: first, participants had to rate the intensity of this symptom during the last 3 days, and second, if this symptom was present, participants had to rate whether they attribute it to current drug intake. |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals who were advised for molar tooth extractions based on orthodontic, periodontal, and endodontic indications
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| Name | Affiliation | Role |
|---|---|---|
| Ammarah Amjad, BDS | Riphah International University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ammarah Amjad | Rawalpindi | Punjab Province | 46000 | Pakistan |
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| ID | Term |
|---|---|
| D007052 | Ibuprofen |
| ID | Term |
|---|---|
| D010666 | Phenylpropionates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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Venous blood was withdrawn, and DNA extraction was performed using Chelex method.
| Drug |
Placebo tablet |
|
| three days |