Reversibility of Methacholine Induced Bronchoconstriction

Salbutamol Reversal of Methacholine Induced Bronchoconstriction: Vibrating Mesh Nebulizer Versus Pressurized Metered Dose Inhaler

The study will compare salbutamol reversibility of methacholine induced bronchoconstriction between a pressurized metered dose inhaler with a spacer versus nebulizer administration using a vibrating mesh nebulizer.

Inclusion Criteria:

• age (years) at least 18, male or female
• no confounding health issue (i.e. no health conditions, other than asthma, that would put the participant at risk or affect data integrity)
• baseline FEV1 ≥ 65% predicted (per Quanjer GLI 2012)
• methacholine PD20 ≤ 800mcg

Exclusion Criteria:

• respiratory infection within 4 weeks of Visit 1
• exposure to triggers of respiratory symptoms within 4 weeks of Visit 1
• currently pregnant or breastfeeding
• current smoker (cigarettes, vaping)