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End-stage renal disease (ESRD) is a rare disease in children. Renal transplantation (RT) is the treatment of choice for ESRD in the pediatric population. In France, around 100 pediatric kidney transplants are performed each year. The aim was to evaluate the surgical management of TR and the long-term results.
End-stage renal disease (ESRD) is a rare pathology in children, whose gold standard treatment is a kidney transplant. In France, around 100 pediatric kidney transplants are performed every year.
Although the first adult kidney transplants were performed in 1954, pediatric renal transplantation was considered unsafe compared with dialysis, which was preferred. In the 1980s, improved graft selection, optimized pre-transplant management and a better understanding of the immune system led to the development of pediatric kidney transplantation.
Despite considerable progress, graft survival in these long-lived patients remains a major challenge.
The aim of this study is to evaluate surgical practices in the four French pediatric transplant centers, and to define risk factors for surgical complications.
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| Measure | Description | Time Frame |
|---|---|---|
| Surgical outcomes | To assess surgical outcome in pediatric renal transplantation in terms of
| 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical complications | Evaluate the surgical morbidity of renal transplantation | 10 years |
| Graft Survival | Evaluate graft survival at 1, 5 and 10 years post transplantation |
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Inclusion Criteria:
Exclusion Criteria:
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All patients from 0 to 18 years who underwent renal transplant for ESRD
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thomas Blanc, Pr | Contact | + 33 1 44 49 41 86 | thomas.blanc@aphp.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| l'hôpital mère-enfant de Lyon | Recruiting | Bron | France |
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| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| 10 years |
| Return to dialysis | Evaluation of the need to return to dialysis after transplantation : causes and reasons | 10 years |
| Retransplantation | Evaluation the number of patient undegoing another transplantation | 10 years |
| Death | Evaluation of the morbidity of this population | 10 years |
| l'hôpital mère enfant de Nantes | Recruiting | Nantes | France |
|
| l'hôpital Robert Debré | Recruiting | Paris | 75019 | France |
|
| l'hôpital Necker Enfants malades. | Recruiting | Paris | France |
|
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |