A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Breath Testing for Small Intestinal Bacterial Overgrowth in Patients Treated With Proton Pump Inhibitors

Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.

Inclusion criteria:

• Predominant symptoms of gastroesophageal reflux disease including heartburn, regurgitation
• Subjects must be able to give appropriate informed consent

Exclusion criteria:

• Prior diagnosis of SIBO
• Use of PPIs or H2R-anatagonstists in the prior 3 months
• Major concomitant illness (renal, hepatic, rheumatologic or cardiovascular disease, or malignancy)
• Antibiotic therapy within one month
• Prior gastrointestinal surgery including esophageal, gastric, and small or large bowel surgery
• Previously diagnosed irritable bowel syndrome or inflammatory bowel disease
• Individuals who are pregnant or breast feeding
• Patients with plans to become pregnant
• Inability to take PPIs, including allergy/sensitivity