Ryme Medical TLD Pilot Study

Targeted Lung Denervation (TLD) With the Ryme Medical Lung Denervation System in Patients With Chronic Obstructive Pulmonary Disease (COPD) - Ryme Medical TLD Pilot Study

Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD) - Ryme Medical TLD Pilot Study

The study is a prospective, multi-center, non-randomized study to evaluate the safety and performance of the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)

Key Inclusion Criteria:

• Symptomatic chronic obstructive pulmonary disease
• ≥40 years of age
• Smoking history of at least 10 pack years
• Candidate for bronchoscopy in the opinion of the Investigator

Key Exclusion Criteria:

• Recent COPD exacerbation or respiratory infection
• Prior lung intervention with device in place
• Pulmonary nodule or malignancy requiring treatment
• Current chemotherapy or radiation therapy and/or has received treatment within 6 months
• Current smoker, using e-cigarettes or vaping, or taking any inhaled substances not prescribed by a physician
• Clinically significant serious or unstable medical conditions (e.g., heart disease requiring treatment, uncontrolled diabetes)
• Pregnant, nursing, or intent to become pregnant during study duration