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The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.9 % Sodium Chloride solution | Experimental | Patients receiving an intravenous infusion of 0.9% NaCl |
|
| 5% Glucose solution | Active Comparator | Patients receiving an intravenous infusion of 5% glucose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Furosemide intravenous infusion | Drug | At baseline, patients will receive a standardised dose of furosemide 1mg/kg (half of the dose administered as bolus and half as in 2h infusion). At the 6th and the 12th hour of the study patients will be reassessed and the need for additional diuretics. |
| Measure | Description | Time Frame |
|---|---|---|
| Urine volume change at individual timepoints during first day of the procedure. | Comparison of urine volume between the groups at individual timepoints during the first day of the procedure. | 24 hours |
| Urine volume change at individual timepoints during second day of the procedure. | Comparison of urine volume between the groups at individual timepoints during the second day of the procedure. | 48 hours |
| Urine composition at individual time points. | Comparison of urine composition (urinary sodium and urinary chloride) between the groups and its change during 72h | 72 hours |
| Cumulative urine output at 24 hours. | Comparison of cumulative urine output between the groups at 24 hours. | 24 hours |
| Cumulative urine output at hours. | Comparison of cumulative urine output between the groups at 48 hours. | 48 hours |
| Total dose of furosemide. | Comparison of the total dose of furosemide between the groups at hours. | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Total time on intravenous furosemide. | The total time on intravenous furosemide between hospital admission and discharge will be calculated. | 3 months |
| Renin-Angiotensin-Aldosterone system activity. |
| Measure | Description | Time Frame |
|---|---|---|
| Body weight | Body weight change after the first day of the procedure. | 24 hours |
| Body weight | Body weight change after the second day of the procedure. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Heart Diseases, Wroclaw Medical University | Wroclaw | Lower Silesian Voivodeship | 50-556 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40455066 | Derived | Biegus J, Iwanek G, Testani J, Zymlinski R, Fudim M, Guzik M, Gajewski P, Ponikowski P. Sodium chloride versus glucose solute as a volume replacement therapy for more effective decongestion in acute heart failure (SOLVRED-AHF): A prospective, randomized, mechanistic study. Eur J Heart Fail. 2025 Nov;27(11):2442-2451. doi: 10.1002/ejhf.3708. Epub 2025 Jun 2. |
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1:1 randomisation to infusion of 0.9% NaCl vs 5% glucose
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|
| Continous intravenous infusion of 0.9% Sodium Chloride solution | Drug | Continuous 48h infusion of 0.9% sodium chloride at a fixed rate v= 83 ml/h x 24h = 2l/24h |
|
| Continous intravenous infusion of 5% Glucose solution | Drug | Continuous 48h infusion of 5% Glucose at a fixed rate v= 83 ml/h x 24h = 2l/24h |
|
Comparison of the renin and aldosterone serum levels between the groups at the 24 hours.
| 24 hours |
| Renin-Angiotensin-Aldosterone system activity. | Comparison of the renin and aldosterone serum levels between the groups at the 48 hours. | 48 hours |
| Heart Failure rehospitalization | Compare the need for Heart Failure rehospitalization within 30 days. | 30 days |
| 48 hours |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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