This retrospective study aimed to evaluate the demographic characteristics, clinical conditions in term of physical examination findings), functional status, and laboratory results of patients with thalassemia minor (TM) and breast cancer (BC) in order to identify any differences between the group with BC only.

Available data as anticancer treatment, comorbidities, weight and height will be combined to report body mass index (BMI) in kg/m2, systolic and diastolic blood pressure, heart rate, ECG, transthoracic echocardiography, blood count, lipid panels, glucose, kidney function tests, (N terminal) NT-proBNP, troponins, handgrip assessments, functional status were extracted from patients files and hospital electronic archives.

Following data was extracted from files and hospital electronic records, and will be evaluated (at baseline, 3, 6, 9 and 12 months):

1. Physical examination findings (as pretibial edema, jugular venous distension, lung rales),
2. Clinically significant changes in cardiac function as determined by Left Ventricular Ejection Fraction (LVEF) measurements using transthoracic echocardiography,
3. Any changes in (N terminal) NT-ProBNP and troponin,
4. Any changes in manual handgrip measurements for both hands using hydraulic hand dynamometer,
5. Applied medications,

were extracted and will be evaluated.

Inclusion Criteria:

1. Patients with diagnosis of breast cancer, and thalassemia minor,
2. >18 years old,
3. Referred by oncologist for cardiac evaluation.
4. Patients with available cardiac evaluations data at baseline and during breast cancer treatment

Exclusion Criteria:

1. Patients without diagnosis of breast cancer, and thalassemia minor,
2. <18 years old,
3. Patients without any cardiac evaluations at baseline, and during cancer treatment.
4. Patients with history of any cardiotoxic treatment prior to enrolment.

Patients diagnosed with breast cancer and thalassemia minor and patients with breast cancer only.

The data underlying this article cannot be shared due to privacy concerns for the individuals who participated in the study. However, after obtaining proper permission from the IRB (Institutional Review Board), a summary of the data at the aggregate level, without individual identifiers, will be made available.