Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury and its protective effects on the cardiovascular system.
This study plans to recruit 60 healthy volunteers, who will be randomly divided into a high-frequency group and a low-frequency group. The high-frequency remote ischemic preconditioning (RIPC) group will undergo RIPC training continuously for seven days, twice daily, with each session consisting of four cycles of 5 minutes of ischemia followed by 5 minutes of reperfusion. The low-frequency RIPC group will follow the same cycle and compression pattern but will train only once a day. Biological samples and physiological indicators will be collected from participants on the day just before the start of ischemic preconditioning training, as well as on the 7th and 14th days following the start of the training. These samples will be analyzed to identify the differences in blood components between groups and at different time points before and after RIPC. The study aims to investigate the effects of different training frequencies of RIPC on the characteristics of peripheral blood in healthy adults, as well as the changes in the peripheral blood characteristics of the participants before and after the training.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A (high-frequency group ) | Experimental | Subjects aged 18 to 45 years and in good health agree to participate in the clinical trial and sign an informed consent form. The high-frequency remote ischemic preconditioning (RIPC) group will undergo RIPC training continuously for seven days, twice daily, with each session consisting of four cycles of 5 minutes of ischemia followed by 5 minutes of reperfusion. |
|
| Group B (low-frequency group ) | Experimental | Subjects aged 18 to 45 years and in good health agree to participate in the clinical trial and sign an informed consent form. The low-frequency RIPC group will follow the same cycle and compression pattern but will train only once a day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischaemic preconditioning | Device | The participants rested in the supine position for 5 minutes, then turn on the ischaemic preconditioning apparatus and place the automatically programmed blood pressure cuff on both upper arms of the participant, pressurize to 200 mmHg, pressurize for 5 minutes, rest for 5 minutes, perform 4 cycles for a total of 40 minutes each time. The training for participants in group A will be performed once daily, while for participants in group B the training will be performed twice daily. And heart rate and blood pressure before and after each training will be recorded for 7 days. |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of changes in various biomarkers between intermediate and intense training group | Difference in collected materials from participants in group A (intermediate RIPC training, once a day) or B (intense RIPC training, twice a day) | Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training |
| Change of peripheral blood characteristics | Peripheral blood characteristics at different remote ischemic preconditioning, training time points, including different fractions and their characteristics expressed by the results of blood tests. | Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training |
| Change of gut microbiome components at different remote ischemic preconditioning training time points | Gut microbiome components | Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of adverse events | Incidence of adverse events related to remote ischemic preconditioning training. The adverse events were decided according to the medical records. | During day 1 to 7 of training. |
| Change of faecal characteristics |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guoliang Li | Contact | 00-86-029-85323805 | liguoliang_med@163.com | |
| Yang Yan | Contact | yangyan3@mail.xjtu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Guoliang Li | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Yang Yan | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xian Jiantong University | Recruiting | Xi'an | Shaanxi | 710061 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
Effect of RIPC training on faecal characteristics, expressed by the fecal test results.
| Baseline (before training), the end of the training day (7th day from the start of training), 7rd day after the end of training |
| Change of blood pressure | Changes in blood pressure at different remote ischemic preconditioning training time points, measured with sphygmomanometer. | Baseline (before training), during the training session (day1-7), 7th day after the end of training. |
| Change of heart rates | Changes in heart rates at different remote ischemic preconditioning training time points, measured with stopwatch. | Baseline (before training), during the training session (day1-7), 7th day after the end of training |