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| Name | Class |
|---|---|
| German Research Foundation | OTHER |
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Aerobic endurance training has shown positive effects on symptoms, cognition, daily functioning, and the structure of the hippocampus in patients with schizophrenia. The study investigates genetic and epigenetic influences on neuroplastic changes following three months of endurance training. A control group performs flexibility, strength, and balance training. The main objective is to examine the association between a genetic risk score for schizophrenia and volume increase in the CA4/DG region of the hippocampus. Additional goals include examining changes in synapses, brain structure, function, and metabolism, as well as clinical symptoms and cognitive performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Group | Experimental | Aerobic endurance training on a bicycle ergometer |
|
| Control Group | Active Comparator | Flexibility, strengthening and balance training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic Endurance Training | Procedure | Aerobic endurance training on a bicycle ergometer (week 1 to 6: three units per week á 40 minutes, week 7 to 12: three units á 45 minutes, in groups of up to three patients over 13 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Hippocampal volume | Change in hippocampal subregion cornu ammonis (CA) 4 volume (∆CA4/DG) and its correlation with polygenetic risk factor (PRS) | 13 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive functions | verbal memory, working memory, motor speed, verbal fluency, attention and speed of information processing assessed by BACS | 13 weeks |
| Executive functions | visual attention and task switching (TMT-A, B), episodic memory with the What-Where-When Test and visuo-spatial short- and long-term memory with the Brief Visuospatial Memory Test-Revised (BVMT-R) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Isabel Maurus, Dr. | Contact | +49 89 4400 55537 | Isabel.Maurus@med.uni-muenchen.de | |
| Lukas Roell, M.Sc. | Contact | +49 89 4400 55812 | Lukas.Roell@med.uni-muenchen.de |
| Name | Affiliation | Role |
|---|---|---|
| Peter Falkai, Prof. Dr. | Director of the Department of Psychiatry and Psychotherapy, University Hospital, LMU | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| LMU Klinikum | Recruiting | Munich | Bavaria | 80336 | Germany |
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| Flexibility, strengthening and balance training | Procedure | Flexibility, strengthening and balance training (exercises from the areas of stretching, strength, balance and relaxation, 3x40 min from week 1-2, 3x45 min from week 3-4 and 3x50 min from week 5-13, in groups of up to three patients over 13 weeks) |
|
| 13 weeks |
| Symptoms severity | change over study duration assessed by PANSS, BNSS, CDSS | 13 weeks |
| Functioning in daily life | Assessed by SOFAS, GAF, FROGS | 13 weeks |
| Cardiovascular risk factors | Aerobic fitness levels (W/kg), body weight, waist circumference, body fat, lipid panel, HbA1c, physical activity as assessed with the IPAQ will be evaluated. | 13 weeks |
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D018583 | Pliability |
| ID | Term |
|---|---|
| D055595 | Mechanical Phenomena |
| D055585 | Physical Phenomena |
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