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Patients will undergo a split-mouth protocol which includes:
a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure.
A study group: in which ozone will be used in addition, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to therapeutic scheme prescribed at the time of discharge.
Primary objective: To evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery.
Secondary objectives:
Patients will undergo a split-mouth protocol which includes:
a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure.
A study group: in which ozone will be used in addition, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to therapeutic scheme prescribed at the time of discharge.
Primary objective: To evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery.
Secondary objectives:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | No Intervention | extraction of the lower third molar will be performed according to the standard protocols of the structure | |
| Trial Group | Experimental | In this group ozone will be used, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to the therapeutic scheme prescribed at the time of resignation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ozone therapy | Other | Ozone in the gaseous state produced by a machine at concentrations for medical use (sssssssssss9) injected after anesthesia in the surgery site and in the post-extraction alveolus after suture.
|
| Measure | Description | Time Frame |
|---|---|---|
| Reduction post operative pain | Evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery. | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paolo Appendino, Dr. | Contact | +390115082222 | pappendino@mauriziano.it | |
| Lucia Borsotti, dr.ssa | Contact | +390115082222 | lborsotti@mauriziano.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| A.O. Ordine Mauriziano | Recruiting | Torino | 10128 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41361069 | Derived | Guaschino L, Vanzanelli A, Babando P, Ricotti A, Ramieri GA, Roccuzzo A, Appendino P. Effect of ozone therapy on post-operative pain following mandibular third molar surgical extraction: a split-mouth randomized clinical trial. Clin Oral Investig. 2025 Dec 9;30(1):2. doi: 10.1007/s00784-025-06681-y. |
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