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Participants are being asked to participate in this research study because they have elected to undergo periacetabular osteotomy (PAO). This research study is looking at if using IV magnesium during surgery can help to reduce pain after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IV Magnesium Sulfate adjuvant group | Experimental | Participants in this group will receive standard-of-care procedures intraoperatively and postoperatively along with IV magnesium sulfate for pain control. |
|
| Control group | No Intervention | Participants in this group will receive standard-of-care procedures intraoperatively and post-operatively for pain control. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IV Magnesium Sulfate | Drug | Participants will receive IV Magnesium Sulfate intraoperatively. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in pain as measured by the Visual Analog Scale (VAS) | The VAS is a scale from 0-10 with 0 being no pain and 10 being the worst pain ever | Over the first 7 days post operatively, measured every 6 hours |
| Change in number of narcotic medications consumed as measured by the medical record review | Over the first 7 days post operatively, gathered every 6 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PROMIS scores | The PROMIS is a 14 item questionnaire is a set of person-centered measures that evaluates and monitors physical, mental, and social health in adults and children. It can be used with the general population and with individuals living with chronic conditions. Scores are typically between 20-80, but may be 0-100. | 2 weeks, 6 weeks, 3 months, 6 months, 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert Wetzel, MD | University Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospitals | Cleveland | Ohio | 44106 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41837581 | Derived | Sinkler MA, Nighswander AJ, Smith KL, Fortier LM, Kodsy MM, Fanaeian E, Salata MJ, Wetzel RJ. MAGNA-PAO: magnesium as an adjuvant for postoperative analgesia in periacetabular osteotomy; a clinical trial protocol. Pain Manag. 2026 Jun;16(6):567-573. doi: 10.1080/17581869.2026.2645536. Epub 2026 Mar 16. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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| Change in modified Harris Hip Scores (mHHS) | The mHHS is a scoring system for functional outcomes post periactabular osteotomies that has a scale of 0-100, 0 being the lowest functional outcome and 100 being the highest | 2 weeks, 6 weeks, 3 months, 6 months, 1 year |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |