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Infantile nystagmus is involuntary, bilateral, conjugate and rhythmic oscillations of the eyes which may present at birth or develop within the first 6 months of life. It may be idiopathic appearing without visual or neurological impairment or may be secondary to an afferent visual defect such as foveal hypoplasia, congenital cataract, retinal dystrophy or optic atrophy. Aiming at improving outcome of head turn in idiopathic infantile nystagmus, comparison between the efficacy and safety of graded Anderson procedure and Kestenbaum procedure is essential.
Infantile nystagmus related abnormal head position is noted according to the axis, it can be anomalous horizontally (right or left head turn), vertically (chin up or down), torsionally (right or left head tilt) or in a mixed pattern. A head turn to right or left is the most common compensatory posture encountered in patients with infantile nystagmus with an eccentric null position. A prolonged head turn (HT) may interfere with the social interactions and the quality of life and may lead to skeletal deformities in the cervical spine with postural dysfunction and impaired movement pattern. Thus, the correction of an abnormal head turn is important to enlarge the visual field, to eliminate the possibility of abnormal contracture of the neck muscles and to permit an adequate vision.Various extraocular muscle surgeries have been advised to correct infantile nystagmus-related HT. Despite being the most common surgical technique used till today for correction of head turn related to nystagmus, Kestenbaum procedure has variable long- term results, limited success rate and involves four rectus muscles (recession/ resection). In graded Anderson procedure, only yoke muscle recession is done based on the amount of initial head turn leaving two untouched muscles.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I (Graded Anderson procedure) | Active Comparator | patients with idiopathic infantile nystagmus related head turn corrected by graded Anderson procedure. |
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| Group II (Kestenbaum procedure) | Active Comparator | patients with idiopathic infantile nystagmus related head turn corrected by Kestenbaum procedure. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Graded Anderson procedure | Procedure | In graded Anderson proceduren only recession of yoke muscles is done. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Degree of head turn | assess the change from Baseline degree of head turn at 6 months postoperatively using protractor goniometer | Base line and 6 months postoperatively. |
| Measure | Description | Time Frame |
|---|---|---|
| Best corrected visual Acuity | assess the change from Baseline best corrected visual acuity at 6 months postoperatively | Base line and 6 months postoperatively |
| stereopsis | assess the change from Baseline stereopsis at 6 months postoperatively using titmus fly test |
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Inclusion Criteria:
Orthophoric Patients with idiopathic infantile nystagmus related head turn (≥20 degrees - ≤ 45 degrees) that is verified at least twice in two separate visits.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gamal Y EL-Mashad, Dr. | professor of ophthalmology, Zagazig University | Study Director |
| Emad M El-Hady, Dr. | professor of ophthalmology, Zagazig University | Study Chair |
| Mostafa A Abdel-Aziz, Dr. | Assisstant professor of ophthalmology, Zagazig University | Study Chair |
| sara F Ibrahim Mahmoud Eid, Master | Assisstant lecturer of Ophthalmology, Zagazig University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zagazig University | Zagazig | Zagazig | 44519 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12234898 | Result | Abadi RV, Bjerre A. Motor and sensory characteristics of infantile nystagmus. Br J Ophthalmol. 2002 Oct;86(10):1152-60. doi: 10.1136/bjo.86.10.1152. | |
| 21061884 | Result | Hertle RW. Nystagmus in infancy and childhood: characteristics and evidence for treatment. Am Orthopt J. 2010;60:48-58. doi: 10.3368/aoj.60.1.48. |
| Label | URL |
|---|---|
| Management of Congenital Nystagmus with and without Strabismus | View source |
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names and affiliations of the participants
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The patients with infantilenystagmus related head turn are divided randomly in two groups according to the surgical procedure to be performed Group I (Graded Anderson procedure);Group II (Kestenbaum procedure)
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| Kestenbaum procedure | Procedure | In Kestenbaum procedure, recession of yoke muscles and resection of their antagonists is done based on Parks table for Kestenbaum procedure according to the preoperative amount of head turn. |
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| Base line and 6 months postoperatively. |
| complications | report intraoperative and postoperative complications | 6 months postoperatively |
| Graded Anderson procedure for correcting abnormal head posture in infantile nystagmus | View source |
| High-dose Anderson operation for nystagmus-related anomalous head turn | View source |