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This study will be conducted to test the cariostatic effect of Nano Silver Fluoride in a comparison to Silver Diamine Fluoride in a group of preschool children.
Silver Diamine Fluoride has offered a non-invasive and easily performed method to manage dental caries in very young children.Studies shows that SDF has been proven to arrest caries in cavitated lesions and to prevent caries in sound teeth as Fluoride is effective in enhancing the remineralization of dental hard tissue and silver ion acts as an antibacterial agent. However, It was found that silver causes staining to the dental tissues with a black discoloration, which can be considered to be a main drawback specifically, when it is used on anterior teeth. Nano-silver fluoride varnish preparation showed high efficacy in arresting caries progression in primary teeth without causing black discoloration to the tissues.Silver diamine fluoride (SDF) .
Benefits for patient:
Benefits for the practitioner:
Benefits for the community:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Silver Diamine Fluoride | Active Comparator | 38% Silver Diamine Fluoride varnish
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| Nano-Silver Fluoride | Experimental | Nano-Silver fluoride varnish preparation
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nano-Silver Fluoride | Drug | NSF is a varnish which has been introduced as experimental formulation . the laboratory synthesis of NSF was carried out in a nano techonolgy center . |
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| Measure | Description | Time Frame |
|---|---|---|
| caries lesion activity and severity assessment using Nyvad criteria | visual and tactile assessment for caries lesion to evaluate the caries progression using Nyvad classification - score from 0 ( normal enamel translucency and texture ) to 9 (carie lesion with filling ) | baseline |
| caries lesion activity and severity assessment using Nyvad criteria | visual and tactile assessment for caries lesion to evaluate the caries progression using Nyvad classification - score from 0 ( normal enamel translucency and texture ) to 9 (carie lesion with filling ) | 3 weeks |
| caries lesion activity and severity assessment using Nyvad criteria | visual and tactile assessment for caries lesion to evaluate the caries progression using Nyvad classification - score from 0 ( normal enamel translucency and texture ) to 9 (carie lesion with filling ) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| ICDAS II | Detection and assessment of dental caries using ICDAS II - assessment done by photographs - score from 0 ( sound ) to 6 ( Extensive cavity with visible dentin ) | baseline |
| ICDAS II | Detection and assessment of dental caries using ICDAS II - assessment done by photographs - score from 0 ( sound ) to 6 ( Extensive cavity with visible dentin ) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo university | Giza | Egypt |
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| ID | Term |
|---|---|
| C024633 | silver diamine fluoride |
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Double blinded study. Participants were blinded towards agents used in the study by using two identical squeezable plastic droppers with tag codes A and B. Also the bio-statistician will be blinded from the meaning of codes.
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| Silver diamine fluoride | Drug | 38% silver diamine fluoride |
|
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| 3 weeks |
| ICDAS II | Detection and assessment of dental caries using ICDAS II - assessment done by photographs - score from 0 ( sound ) to 6 ( Extensive cavity with visible dentin ) | 6 months |