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Dynamic 99mTc-Tetrofosmin CZT-SPECT myocardial perfusion imaging (MPI) is an advanced functional imaging technique giving important myocardial flow quantification added data in comparison with conventional MPI, especially in coronary multi vessel disease. A large-scale validation of diagnostic performances of myocardial flow reserve (MFR) estimated with Dynamic 99mTc-Tetrofosmin CZT-SPECT MPI would allow a non-invasive approach instead of invasive intra-coronary fractional flow reserve (FFR) measurement. The aim of this prospective study is to assess diagnostic performances of MFR calculated with dynamic 99mTc-Tetrofosmin CZT-SPECT MPI in comparison with invasive intra-coronary FFR measurement in patients with significant residual coronary arteries stenosis after acute coronary syndrome .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single arm study | Experimental | Patients included in the study will undergo subsequently at 1-month after acute coronary syndrome Dynamic 99mTc-Tetrofosmin CZT-SPECT followed by FFR and IMR assessment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dynamic 99mTc-Tetrofosmin CZT-SPECT | Diagnostic Test | Patients included in the study will undergo subsequently at 1-month after acute coronary syndrome Dynamic 99mTc-Tetrofosmin CZT-SPECT followed by FFR and IMR assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity, specificity, predictive positive value, negative predictive value, accuracy of MFR in comparison with FFR | To determine MFR diagnostic performances in comparison with FFR | within one month after ST-elevation myocardial infarction |
| Measure | Description | Time Frame |
|---|---|---|
| best MFR cut-off value | To determine the best MFR cut-off value correlated with FFR value < 0.8 | within one month after ST-elevation myocardial infarction |
| MFR value correlated with IMR | analysis of discrepancies between MFR value correlated with IMR (if low MFR value and normal FFR value) |
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Inclusion Criteria:
Adult patient.
Multi vessel coronary arteries disease (at least one non-culprit coronary stenosis >= 50%) diagnosis during
Written consent.
Social security affiliation
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | 44093 | France |
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| within one month after ST-elevation myocardial infarction |
| Sensitivity, specificity, predictive positive value, negative predictive value, accuracy of MFR in comparison with conventional static MPI | To determine MFR diagnostic performances in comparison with conventional static MPI | within one month after ST-elevation myocardial infarction |
| Sensitivity, specificity, predictive positive value, negative predictive value, accuracy of QFR in comparison with FFR value | QFR value at the index procedure in comparison with FFR value | within one month after ST-elevation myocardial infarction |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
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