Impact of Milk Fat Globule Membrane Supplementation on Heart and Brain Health

Impact of Short-term Supplementation with a Milk Fat Globule Membrane-enriched Powdered Ingredient on Cardiometabolic and Cognitive Health Outcomes

In a randomised, controlled cross-over manner, this trial aims to determine how short-term daily supplementation with a milk fat globule membrane-enriched ingredient impacts on cardiometabolic health and cognitive outcomes.

Inclusion Criteria:

• Aged 40 - 70 years
• BMI: 25-45 kg/m2
• Recreationally active (> 3 x 30 min moderate exercise per week)
• Understands and is willing and able to comply with all study procedures, including changes to diet
• Fluent in written and spoken English
• Access to, and able to use, the internet/computer/tablet device

Exclusion Criteria:

• Smoking (including vaping)
• Unstable weight history (≥3 kg loss or gain in the previous 3 months) or planning or currently on a weight reduction scheme
• Currently taking part or have participated in another research study in the last two months (e.g., dietary intervention)
• Diagnosed with cardiovascular disease or suffered myocardial infarction/stroke in the past twelve months
• Existing or significant past medical history of any medical condition likely to affect the study outcomes.
• Prescribed medications or supplements likely to interfere with study outcomes or prescribed antibiotics within the last three months
• Use of antidepressant/anti-anxiety medication if it has changed in the last three months or expected to change within the 3-month study period.
• Known allergy or intolerance to study food (lactose intolerance, dairy)
• Being vegan or any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention or metabolic study
• Excessive alcohol consumption: >21 unit/wk
• Pregnancy, seeking to become pregnant or active lactation