Ketogenic Diet Health and Longevity

Pilot Investigation of the Ketogenic Diet's Health Effects Through Multi-Omics Assessment

The goal of this pilot intervention is to learn about how a well-formulated ketogenic diet (WFKD) impacts various health factors in generally healthy adults. The main questions it aims to answer are:

• Establish whether an 8-week isocaloric, WFKD improves body composition and metabolic biomarkers in adults without chronic disease.
• Examine changes in transcriptomic sequencing pathways pre- and post-WFKD intervention.
• Explore gut microbial changes in adults without chronic disease that consume a WFKD.

Participants will follow a well-formulated ketogenic diet for 8-weeks. Study procedures include:

• Weekly body weight tracking
• Daily urinary ketone assessment
• Pre/post stool samples for gut microbiota analyses
• Pre/post DXA scans
• Diet quality tracking through 3-day food records

Inclusion Criteria:

• 30 to 55 years
• Speaks English as primary language
• BMI 20.0-34.9 kg/m^2

Exclusion Criteria:

• Certain medications (statin, blood pressure, thyroid hormone replacement, etc.)
• Prior medical diagnosis of type 1 or type 2 diabetes mellitus, cancer requiring chemotherapy or radiation therapy within 5 years, cardiac event, GI disorders, traumatic brain injury/multiple concussions, hypertension, dyslipidemia, or any diagnosis deemed ineligible by study team
• History of renal stones
• Currently lactating
• Already following a ketogenic diet
• Adherence to a specialized diet regimen that disallows compliance
• Use of tobacco or tobacco replacement products within 1 year