Osteoarthritis (OA) is one of the most frequent causes of pain and disability in adults. According to the Osteoarthritis Research Society International (OARSI), at least 40% of people over the age of 65 suffer from symptomatic osteoarthritis of the hip or knee. Knee osteoarthritis (OA) is the eleventh leading cause of years lived with disability according to the World Health Organization.

The guidelines show that treatment with intra-articular injections of hyaluronic acid (HA) leads to a slow, prolonged pain relief (up to six months after the first injection); On the other hand, there is little evidence in the literature about the intra-articular use of isolated collagen or in combination with hyaluronic acid in the treatment of knee osteoarthritis.

The present study showed a clinically good safety profile and provided preliminary evidence of the efficacy of NEOIAL HC for the treatment of symptomatic knee OA

Inclusion Criteria:

• Age
• Knee OA
• VAS > 3
• Kellegren radiographic stage 3-4

Exclusion Criteria:

• presence of joint effusion,
• VAS score <3 according to the American College of Rheumatology Criteria
• neoplasms,
• haematological diseases,
• specific rheumatological pathologies,
• bleeding disorders, local infections,
• refusal or non-compliance of the patient,
• candidacy for knee joint replacement or any intra-articular injection during the previous year,
• addiction to opioid drugs,
• recent heart attack or stroke.