Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The distinction between self-generated and external information is impaired in patients with schizophrenia, who are assumed to confuse imagination with real perceptions. To better understand the underlying mechanisms of these abnormalities, the investigator will investigate the brain mechanisms supporting auditory externalization. Auditory externalization is the ability to perceive whether a sound comes from inside or outside oneself. Our study, in healthy participants, will use functional brain imaging to identify the brain areas involved in the externalization of sound sources and to test whether neuromodulation of this area can modify this ability and provide a therapeutic lead in pathological populations
30 healthy participants will be included. The participants will undergo three separate visits. During the first one, the participants will listen to sounds coming from either internal or external sources while undergoing an fMRI session. This will allow us to identify the brain region involved in externalizing abilities with the highest activity. In the second and third visits, this specific region will be targeted by HD-tDCS (a non-invasive high-definition neuromodulation technique whose precision is enhanced by individual data) to modulate its activity and test its causal involvement in externalization processes. Each participant will receive both active and placebo stimulation, with the order counterbalanced. During the stimulation, participants will complete an externalization task, followed by a reality monitoring task and a self-agency task. Additionally, the investigator will gather socio-demographic and psychometric data.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 15 healthy participants active then placebo | Active Comparator | 15 healthy participants will receive a session of active HD-tDCS and then a session of placebo HD-tDCS. |
|
| 15 healthy participants placebo then active | Placebo Comparator | 15 healthy participants will receive a session of placebo HD-tDCS and then a session of active HD-tDCS. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-definition transcranial direct current (HD-tDCS), active condition | Procedure | Participants will receive a session of active HD-tDCS at a current intensity of 2 mA for a duration of 25min. The placement of electrodes will be determined to specifically target the brain area that has been identified as being involved in the process of externalization, as evidenced by fMRI. During the stimulation, participants will be engaged in a computer-based externalization task. |
| Measure | Description | Time Frame |
|---|---|---|
| Externalization abilities | proportion of sounds perceived as coming from an external source in the externalization task (range 0-100%) | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Reality monitoring performance | Scores obtained at the reality monitoring task (Brunelin et al., 2006) (accuracy, range = 0-100%) | one year |
| Self-agency | Percentage of voice deviation in the self-agency task (Subramaniam et al., 2018) (pitch perturbation and variability in peak deviation in cents, cents(t) = 1200 log2 (Hertz(t )/HertzRef), mean pitch perturbation response tracks = ±100 and ± 400) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marine MONDINO, PhD | Contact | 0437915565 | +33 | marine.mondino@ch-le-vinatier.fr |
| Lydie SARTELET | Contact | 0437915531 | +33 | lydie.sartelet@ch-le-vinatier.fr |
| Name | Affiliation | Role |
|---|---|---|
| Marine MONDINO, Phd | hospital le Vinatier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier le Vinatier | Recruiting | Bron | 69678 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Double-blind, placebo-controlled, randomized crossover study including 30 healthy participants who will receive active and placebo HD-tDCS in a counterbalanced order.
Not provided
Not provided
Participants and experimenters (including tDCS operator) will not be informed about the nature (active or placebo) of the stimulation they will receive.
|
| High-definition transcranial direct current (HD-tDCS), placebo condition | Procedure | Participants will receive a session of placebo HD-tDCS, which will be delivered following the same procedures as active HD-tDCS but the intensity of the current will be set at 2mA during the 30 first seconds at the beginning of the 25-min period of the stimulation, and equal to 0 mA for the reminding period of stimulation to simulate the tingling sensation often experienced by individuals during active stimulation. The placement of electrodes will be determined to specifically target the brain area that has been identified as being involved in the process of externalization, as evidenced by fMRI. During the stimulation, participants will be engaged in a computer-based externalization task |
|
| one year |
| Psychometric characteristics that may influence externalization abilities and stimulation effects | Launay-Slade Hallucinations Scale scores between 0 and 64 (LSHS; Launay and Slade) | baseline |
| Psychometric characteristics that may influence externalization abilities and stimulation effects | Plymouth Sensory Imagery Questionnaire (PSIQ).Scores between 0 and 70. | baseline |
| Side effects of stimulation | Scores at the questionnaire on side effects of stimulation. Scores between 10 and 44 (higher scores mean worse outcome) | 1 time before (baseline) and within 1 hour after stimulation |
| Mood | Mood self-questionnaire. Scores between 0 and 100 (higher scores mean worse outcome) | 1 time before (baseline) and within 1 hour after stimulation |