Most psychiatric research is based on the nosographic classifications used in current practice. At present, there is no diagnostic or prognostic biomarker for psychiatric pathologies commonly used in clinical practice. The study hypothesis is that peripheral inflammatory biomarkers could be common to several psychiatric disorders, in particular psychotic disorders (bipolar disorder, schizophreniform disorder, schizophrenia, depressive episode with psychotic features). The aim of this project is to set up a bio-collection of biological samples (peripheral blood samples) with associated phenotypic data (assessment of various symptoms using standardized scales in patients whose blood is sampled). The setting up of this cohort follows on from work carried out on a PsyCourse cohort also using a transdiagnostic approach in psychiatry, in order to be able to collaborate within a European research project.

Inclusion Criteria:

• Major patient

• Patient with one of the following diagnoses confirmed by a psychiatrist:

  • Characterized depressive episode with psychotic features,
  • Bipolar disorder type I
  • Bipolar disorder type II
  • Schizoaffective disorder
  • Schizophrenia
  • Schizophreniform disorder

• Patient under psychiatric care at Nantes University Hospital

• Patients weighing at least 45kg

• Patient affiliated to a social security scheme or beneficiary of such a scheme

• Patient who has given informed consent to participate in the study

Exclusion Criteria:

• Pregnant,
• History of cancer in the last 5 years,
• Vaccination within the last 4 weeks,
• Acute or chronic infection,
• Medical history of organ transplant,
• Medical history of autoimmune disease,
• Hearing impairment making it impossible to complete study questionnaires,
• Patient under court protection

Participants will be recruited through the doctors who care for them on a regular medical basis, during a consultation or hospitalization in a psychiatric unit. After inclusion, an additional blood sample (4 tubes with a peripheral venous sample) will be taken by nurses from the psychiatric wards caring for the patient, during a blood sample taken as part of the patient's care. The sample will be transported to the Biological Resource Center (CRB) at Nantes University Hospital, where it will be stored along with all other study samples.