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The actual quality of Red Blood Cells (RBCs) salvaged during spinal deformity surgery has never been rigorously evaluated. To characterize the usefulness of intraoperatively salvaged RBCs in spinal deformity surgery. The study team hopes to answer the following questions: 1) What is the quality of RBCs salvaged during spine surgery? 2) Does intraoperatively transfused RBC salvage impact clinical outcomes?
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| Measure | Description | Time Frame |
|---|---|---|
| Lactate Dehydrogenase (LDH) Levels | LDH assays will be performed following a standardized mechanical stress test will be used to determine whether salvaged red blood cells exhibit signs of fragility ex vivo. | Day 1 (Day of Surgery) |
| Hemoglobin Levels | Hemoglobin assays will be performed following a standardized mechanical stress test will be used to determine whether salvaged red blood cells exhibit signs of fragility ex vivo. | Day 1 (Day of Surgery) |
| Elongation Index (Deformability) | Ektacytometry will be employed to measure elongation index of salvaged RBCs. | Day 1 (Day of Surgery) |
| Critical Shear Stress (Aggregation) | Ektacytometry will be employed to measure critical shear stress of salvaged RBCs. | Day 1 (Day of Surgery) |
| Measure | Description | Time Frame |
|---|---|---|
| Standardized Quantified Blood Loss (mL) | Day 1 (Day of Surgery) | |
| Use of Cell Saver | This will be reported in a binary manner: 0 = yes, 1 = no | Day 1 (Day of Surgery) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing any spine surgery that utilizes Cell Saver and has blood to be given back.
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| Name | Affiliation | Role |
|---|---|---|
| Darryl Lau, MD | NYU Langone Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NYU Langone Health | New York | New York | 10016 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39087785 | Derived | Kurland DB, Alber D, Smith A, Ahmed S, Orringer D, Frempong-Boadu A, Lau D. What Are We Transfusing? Evaluating the Quality and Clinical Utility of Intraoperatively Salvaged Red Blood Cells in Spinal Deformity Surgery: A Nonrandomized Controlled Trial. Neurosurgery. 2024 Nov 1;95(5):976-985. doi: 10.1227/neu.0000000000003131. Epub 2024 Aug 1. |
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| Volume (mL) collected via Cell Saver | Day 1 (Day of Surgery) |
| Units of autologous blood transfused intraoperatively | Day 1 (Day of Surgery) |
| Units of allogeneic blood transfused intraoperatively | Day 1 (Day of Surgery) |
| Units of allogeneic blood transfused postoperatively | Day 1 (Day of Surgery) |
| Duration of pressor use | 1 Day (Day of Surgery) |