Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 22-01741 | Other Grant/Funding Number | American College of Sports Medicine |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of acute kidney injury.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental Arm: Whole-body Passive Heat Therapy (HT) | Experimental | Heat therapy will be administered using an infrared sauna. The intervention duration will last 25 minutes at a temperature of 60°C. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole-body Passive Heat Therapy (HT) | Procedure | The whole-body passive heat therapy (HT) intervention will consist of an acute bout of infrared sauna for 25 minutes at 60°C. Participants will lie supine on a memory foam pad. |
| Measure | Description | Time Frame |
|---|---|---|
| Renal Safety of Heat Therapy | Change in urinary NGAL | Change from baseline to 90 minutes after intervention |
| Tolerability of Heat Therapy as Assessed using Validated Questionnaires of Thermal Perception | Self reported perception of heat using the the Thermal Sensation Scale. | During 25 minute intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Conduit artery endothelial function | Brachial artery flow-mediated dilation assessed by high-resolution duplex ultrasound. | 90 minutes after intervention |
| Lower Limb Microvascular Function | Lower limb microvascular function will be assessed with high-resolution duplex ultrasound during passive leg movement (PLM) technique. |
Not provided
Inclusion Criteria for participants with CKD:
Exclusion Criteria for participants with CKD:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Danielle Kirkman, PhD | Virginia Commonwealth University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Virginia Commonwealth University | Richmond | Virginia | 23220 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Thermoneutral Control (CON) | Procedure | Participants will remain in a room temperature environment (22°C) underneath the infrared domes for 25 minutes. |
|
| 90 minutes after intervention |
| Exercise Capacity | The 6-minute walk test distance. | 90 minutes after intervention |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |