This is a prospective, open-label, randomized, parallel controlled clinical trial. The purpose of this study is to understand the application value of plasma-activated normal saline in the treatment of different types of wounds. The main questions it aims to answer are:

1. What is the effect of plasma activated normal saline in promoting wound healing of different types?
2. What is the safety of plasma activated normal saline in the treatment of wound surface? Subjects will be randomly divided into the intervention group and the control group. The intervention group will receive wound treatment with plasma activated normal saline, and the control group will receive routine dressing change treatment.

As the population ages and antibiotic resistance increases, the chance of co-infection of various types of wounds increases greatly, resulting in prolonged wounds healing and eventually leading to bloodstream infections caused by germs, which can develop into life-threatening sepsis in severe cases. Plasma active saline is rich in reactive oxygen groups (ROS) and reactive nitrogen groups (RNS). It has good anti-inflammatory effect and is a potential new material to control wound infection and promote wound healing. Therefore, the purpose of this study was to apply plasma-activated water to different types of wounds and evaluate the effect of plasma-activated water on promoting healing of different types of wounds. And security issues in the application process.

This study is a prospective, open label, randomized, parallel controlled trial. This study is expected to include 162 subjects, including 46 patients with postoperative incision infection, 34 patients with postoperative incision fat liquefaction, and 82 patients with cutaneous infectious ulcer. The participants will be randomly divided into intervention group and control group by grouping randomized method. The intervention group will be treated with plasma activated water flushing and wet compress, and the control group will be treated with routine dressing change. The investigators will collect participants' wound conditions, blood, microbiological tests and other relevant indicators during treatment and follow-up.

To analyze the efficacy and safety of plasma-activated saline in the treatment of different wounds, the investigators will use independent sample T-test and K-M methods to compare the efficacy of the two groups, use descriptive analysis to represent the type and frequency of adverse events.

1. Inclusion Criteria

   1. Group of postoperative incision infection

      • Age ≥18 years old, ≤75 years old, gender unlimited.
      • Clinical diagnosis of postoperative incision infection.
      • Must be no significant risk of head trauma or closed injury to the chest and abdomen.
      • Fully understand the study content and subjects' rights and interests, and sign the informed consent.

   2. Group of postoperative incision fat liquefaction

      • Age ≥18 years old, ≤75 years old, gender unlimited.
      • Clinical diagnosis of postoperative incision fat liquefaction.
      • Must be no incision infection or organ infection was involved in deep surgery, and no other serious complications occurred.
      • Must be no significant risk of head trauma or closed injury to the chest and abdomen.
      • Fully understand the study content and subjects' rights and interests, and sign the informed consent.

   3. Group of infectious ulcers

      • Age ≥18 years old, ≤75 years old, gender unlimited.
      • Clinical diagnosis of superficial skin ulcer infection caused by various causes, which can have one or more wounds.
      • The formation time of the wound surface exceeds 1 month.
      • Fully understand the study content and subjects' rights and interests, and sign the informed consent.

2. Exclusion Criteria

   • Allergic to multiple drugs, dressings, gels or materials used in this study.
   • Functional injury of cardiopulmonary system, with obvious risk of craniocerebral trauma or severe closed injury of chest and abdomen.
   • Severe malnutrition, hypoproteinemia, moderate to severe anemia.
   • Pregnant or lactating women (lactating female subjects can still be included if they agree to stop breastfeeding during the treatment period and within one week after the last medication).
   • Patients with active wound bleeding, poor mental condition and critical condition.
   • Poor glycemic control of diabetes mellitus; Severe malnutrition, hypoproteinemia, moderate and severe anemia.
   • The presence of inflammatory skin diseases, such as atopic dermatitis or eczema, that affect efficacy and safety evaluation.
   • Poor glycemic control of diabetes mellitus; Severe malnutrition, severe cardiopulmonary disease, hypertension, widespread local necrosis requiring immediate toe amputation.
   • Combined with anaerobic bacteria infection, wet gangrene, abdominal infection, hematogenous infection, and intra-articular infection.
   • Ulcers caused by diabetic feet and malignant tumors.
   • History of glucocorticoid use and anticoagulant drug use within 12 months before enrollment.
   • History of immune disease or immunosuppressant use.
   • Poor compliance due to cognitive impairment or mental illness.
   • Any conditions that the investigator considered might increase the risk to the subject or affect the evaluation of efficacy.