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To explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.
Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries. It is a serious knee injury. The fracture of ACL can cause functional instability of knee joint, damage of meniscus and articular cartilage, and even induce knee osteoarthritis and other diseases. It has great influence on knee joint and even lower limb function of patients. Arthroscopic ACL reconstruction has become the first choice in clinical treatment of ACL fracture.
ACL fracture can cause local knee joint osteoporosis, and reconstruction surgery can also affect tendon bone healing, bone canal enlargement, rehabilitation period, gait, articular cartilage degradation, etc.
This study intends to conduct preoperative rehabilitation intervention for young people with anterior fork rupture, and explore the effects of exercise rehabilitation on knee bone mineral density, muscle strength, proprioceptive ability and other aspects after ACL rupture, as well as the effects of knee bone mineral density, tendon bone healing, bone tunnel aperture, motor function, gait characteristics and cartilage degradation after reconstruction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental group | Experimental | Before ACL reconstruction,40 minutes of rehabilitation training was performed 3 times a week for 6 weeks, and gotted regular treatment. The ACL reconstruction was followed by a 0.5 year rehabilitation. |
|
| control group | Active Comparator | Regular rehabilitation training was not performed before ACL reconstruction, got regular treatment. The ACL reconstruction was followed by a 0.5 year rehabilitation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise rehablitation | Behavioral | Preoperative exercise rehabilitation in experimental group was performed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Grade of tendon bone healing | tendon bone healing by knee MRI | At 6 monthes post operation. |
| Grade of tendon bone healing | tendon bone healing by knee MRI | At 1 year post operation. |
| balanced capacity | Y balance test | At preoperative. |
| balanced capacity | Y balance test | At 6 monthes post operation. |
| balanced capacity | Y balance test | At 1 year post operation. |
| knee T1 rho value | knee T1 rho value by functional MRI | At 6 months post operation. |
| knee T1 rho value | knee T1 rho value by functional MRI | At 1 year post operation. |
| knee T2 value | knee T2 rho value by functional MRI | At 6 months post operation. |
| knee T2 value | knee T2 rho value by functional MRI |
| Measure | Description | Time Frame |
|---|---|---|
| The HU value of CT | CT test | at pre-operation |
| Thigh Circumference | the circumference of 15 cm above the superior aspect of the patella |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shuang Ren | Contact | 17610252992 | xixishuang123@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Recruiting | Beijing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42374474 | Derived | Wu Y, Yan W, Dai W, Ren S, Ao Y, Gong X. The effect of preoperative rehabilitation exercises on postoperative bone mineral density, tendon-bone healing, and physical function after anterior cruciate ligament reconstruction: a multi-center randomized controlled clinical trial. BMC Sports Sci Med Rehabil. 2026 Jun 30. doi: 10.1186/s13102-026-01841-3. Online ahead of print. |
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Can contact the author to communicate and obtain the corresponding data.
1/6/2025-1/9/2025
Relevant data on bone mineral density and physical function can be accessed through the ClinicalTrials.gov website.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 10, 2025 | Jun 29, 2025 |
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| routine treatment | Behavioral | The control group receives conventional treatment preoperative. |
|
| At 1 year post operation. |
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. |
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 1 year post operation. |
| Graft maturity | tendon bone healing by knee MRI | At 6 monthes post operation. |
| Graft maturity | tendon bone healing by knee MRI | At 1 year post operation. |
| bone mineral density | bone mineral density by knee DEX | At preoperative. |
| bone mineral density | bone mineral density by knee DEX | At 6 monthes post operation. |
| bone mineral density | bone mineral density by knee DEX | At 1 year post operation. |
| isokinetic muscle strength | Knee isokinetic strength test | At preoperative. |
| isokinetic muscle strength | Knee isokinetic strength test | At 6 monthes post operation. |
| isokinetic muscle strength | Knee isokinetic strength test | At 1 year post operation. |
| Grade of tendon bone healing | tendon bone healing by knee MRI | At 2 years post operation. |
| balanced capacity | Y balance test | At 2 years post operation. |
| Graft maturity | tendon bone healing by knee MRI | At 2 years post operation. |
| isokinetic muscle strength | Knee isokinetic strength test | At 2 years post operation. |
| At 2 years post operation. |
| Thigh Circumference | the circumference of 15 cm above the superior aspect of the patella | At 1 year post operation. |
| Thigh Circumference | the circumference of 15 cm above the superior aspect of the patella | At 6 monthes post operation. |
| Thigh Circumference | the circumference of 15 cm above the superior aspect of the patella | At pre-operation. |
| Single-Leg Hop | a maximal-distance hop | At 1 year post operation. |
| Single-Leg Hop | a maximal-distance hop | At 2 years post operation. |
| Prot_001.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Jun 10, 2025 | Jun 29, 2025 | SAP_002.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 10, 2025 | Jun 29, 2025 | ICF_003.pdf |
| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
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