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| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A00475-40 | Other Identifier | ID-RCB |
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Fabry disease (OMIM-301500, FD) is a lysosomal storage disease with X-linked inheritance secondary to mutations in the α-galactosidase A gene (GLA), which cause absence or decreased activity of the lysosomal hydrolase a-galactosidase A (a-gal A). The accumulation of globotriaosylceramide (Gb3) leads to multiple organs dysfunction, especially in three key organs: kidney, heart and cerebrovascular system. Progressive nephropathy is one of the main features of Fabry disease and is marked by an insidious development. The investigators are facing different current challenges about treatment initiation in non-classic phenotype patients, optimal dose after treatment initiation, and treatments monitoring in Fabry nephropathy. That is even more important that the enzyme replacement therapy is expensive and a lifelong commitment.
Functional magnetic resonance imaging (MRI) is now able to provide T1 mapping sequence. In Fabry disease, T1 mapping is currently used to assess the degree of myocardial involvement. The MRI for assessement of Fabry Cardiomyopathy is now recommended by the 2022 national diagnostic and care protocol (PNDS) in France. However there is no data about T1 mapping values in kidney in Fabry's disease The main Objective is to describe renal performance through multi-parametric MRI in Fabry nephropathy and the primary outcome will be the quantification of renal T1 in Fabry patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fabry disease | Other |
| |
| Patients undergoing renal functional exploration | Other | Patients undergoing renal functional exploration for a reason other than Fabry disease, amyloidosis, hemochromatosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| T1 mapping measurement | Diagnostic Test | T1 mapping values to test the ability of the MRI sequence to detect Gb3 in kidney |
|
| Measure | Description | Time Frame |
|---|---|---|
| T1 value measured | Difference in the measurement of T1 mapping by MRI in Fabry disease patients compared with controls. T1 mapping is a MRI sequence to estimate renal fibrosis | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Apparent diffusion coefficient (ADC) coefficient values | ADC coefficient values to measure the degree of fibrosis in Fabry nephropathy in Fabry disease patients compared with controls. | Day 1 |
| R2* coefficient values |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Edouard Herriot | Lyon | 69003 | France |
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| ID | Term |
|---|---|
| D000795 | Fabry Disease |
| ID | Term |
|---|---|
| D013106 | Sphingolipidoses |
| D020140 | Lysosomal Storage Diseases, Nervous System |
| D020739 | Brain Diseases, Metabolic, Inborn |
| D001928 | Brain Diseases, Metabolic |
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R2* values to measure the degree of renal alteration in Fabry nephropathy in Fabry disease patients compared with controls.
| Day 1 |
| T2 value measured | Comparison of T2 values measured by T2 mapping MRI between patients with Fabry disease and controls. T2 mapping is a MRI sequence to estimate renal alteration | Day 1 |
| T1 mapping measurement Fabry disease | Comparison of T1 mapping values within 3 different subgroups of patients with Fabry disease (treated men, treated or untreated women) | Day 1 |
| In Fabry disease patients, evaluation of the association between the T1 values measured and concentration of plasma globotriaosylsphingosine (LysoGb3) | Day 1 |
| In Fabry disease patients, evaluation of the association between glomerular filtration rate and ADC value measured | ADC value measured by diffusion-weighted MRI | Day 1 |
| In Fabry disease patients, evaluation of the association between glomerular filtration rate and R2* value measured | R2* value measured by blood oxygen level-dependent (BOLD) MRI | Day 1 |
| In Fabry disease patients, evaluation of the association between glomerular filtration rate and T2 value measured | T2 value measured by T2 mapping MRI | Day 1 |
| In Fabry disease patients, evaluation of the association between proteinuria and ADC value measured | ADC value measured by diffusion-weighted MRI | Day 1 |
| In Fabry disease patients, evaluation of the association between proteinuria and R2* value measured | R2* value measured by BOLD MRI | Day 1 |
| In Fabry disease patients, evaluation of the association between proteinuria and T2 value measured | T2 value measured by T2 mapping MRI | Day 1 |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D059345 | Cerebral Small Vessel Diseases |
| D002561 | Cerebrovascular Disorders |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D040181 | Genetic Diseases, X-Linked |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008661 | Metabolism, Inborn Errors |
| D008064 | Lipidoses |
| D008052 | Lipid Metabolism, Inborn Errors |
| D016464 | Lysosomal Storage Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D052439 | Lipid Metabolism Disorders |