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The study could not be conducted as a randomized controlled study due to a change in the protocol, and the study needs to be stopped.
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To verify the effect of feeding milk powder rich in medium chain fatty acids on improving the nutritional status and disease status of infants with cholestatic liver disease and To evaluate the safety of feeding milk powder rich in medium chain fatty acids in infants with cholestatic liver disease.
This study will include all types of cholestatic liver disease in infants, randomized controlled study of the efficacy and safety of intervention with rich medium chain fatty acid milk powder,To verify the effect of feeding milk powder rich in medium chain fatty acids on improving the nutritional status and disease status of infants with cholestatic liver disease .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rich medium chain fatty acid milk powder group | Experimental | This group will be fed milk powder rich in medium-chain fatty acids. The MCT content of formula milk is 39%, and the total energy is 68kcal/100ml. |
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| Regular milk powder group | Active Comparator | This group will be fed regular milk powder.The MCT content of formula milk is less than 30%, and the total energy is 67kcal/100ml. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rich medium chain fatty acid milk powder group | Dietary Supplement | In intervention group,there are 32 infants.They will be fed with rich medium chain fatty acid milk powder, formula with MCT content of 39%, total energy of 68kcal/100ml, and feeding frequency at a 3-hour interval |
| Measure | Description | Time Frame |
|---|---|---|
| Z-scores of weight for age | The change of WAZ would be calculation at the 4 weekend(28 days) after enrollment. | "from enrollment to the 4 weekend(28 days)" |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Children's Hospital of Fudan University Children's Hospital of Fudan University | employee | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| zhaoyang Gou | Shanghai | China |
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| Regular milk powder group | Dietary Supplement | In control group,there are 32 infants.They will be fed regular milk powder,formula with MCT content of less than 30%, total energy of 67kcal/100ml, and feeding frequency at a 3 hours interval |
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