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The aim of this study is to investigate the early changes in macular thickness, corneal thickness and intraocular pressure in young women undergoing surgical menopause.
Methods: Eye findings of 30 surgical menopausal (Postoperative 3-6 months) and 48 natural menopause and 22 healty women (control) were evaluated using OCT. Women with no known eye disease, no chronic disease (Diabetes Mellitus, Cardiac Disease any Autoimmune disease) and no migraine in addition to non smokers were included in the study. Women using any hormone and obese women ( BMI >25 kg/m2) were excluded. Macular and corneal thickness and intraocular pressure (IOP) were measured in both eyes of the women
This prospective case control study was conducted in a tertiary gynecology and obstetrics clinic and eye clinic between 2020 and 2021 with ethics committee approval number 2020 250 ). Informed consent form was obtained from all participants. All participants were outpatients who applied to obstetrics clinic in Batman Training and Research Hospital.
The study started with 105 patient. Based on the study exclusion criteria, 7 patients were excluded from the study. Every patient in the surgical menopause group underwent a hysterectomy and bilateral salpingo-oophorectomy for benign uterine reasons. The patients included in the study were menstruating women with preoperative natural ovarian appearance and benign non ovarian indications, who had undergone hysterectomy and bilateral salpingo-oophorectomy and had no preoperative menopause complaints. Patients younger than 52 years of age who have undergone oophorectomy are patients whose ovaries have been removed either because of patient anxiety due to a family history of cancer or because of adhesions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1( Surgical menopause) | Surgical menopause : At least 6 months after hysterectomy and salphingo-oopherectomy |
| |
| 2 ( Natural menopause ) | Natural menopause :Healthy female patients who have not had a menstrual period for at least 1 year and have not received any treatment for this reason before |
| |
| 3 (Control ) | Healthy women aged 30-45 years with regular menstrual cycles and no symptoms of menopause |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optic coherence tomography | Diagnostic Test | Eye examination of patients with optic coherence tomography test by an ophthalmologist |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effect of surgical menopause on corneal and macular thickness | To question the effect on macular and corneal thickness secondary to sudden ovarian hormone change with surgical menopause. | 6 months after hysterectomy and bilateral salpingo-oopherectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Eye examination needed after surgical menopause | To seek an answer to the question of adding eye diseases examination to the examinations of post-surgical menopause patients. | 6-12 months |
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Inclusion Criteria:
Exclusion Criteria:
Female ,age between 30-55 .
Patient selection was made between surgical menopause, natural menopause and healthy women who have given birth before.
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| Name | Affiliation | Role |
|---|---|---|
| Erhan Okuyan | Batman Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Batman education adn research hospital | Batman | 72100 | Turkey (Türkiye) |
Will be given to the journal upon request.
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