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| ID | Type | Description | Link |
|---|---|---|---|
| J1I-MC-GZBT | Other Identifier | Eli Lilly and Company |
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The main purpose of this study is to measure how much of LY3437943 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to healthy participants with normal liver function. The safety and tolerability of LY3437943 will also be evaluated. The study may last up to 9 weeks for each participant including the screening period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LY3437943 (Normal Hepatic Function) | Experimental | LY3437943 administered subcutaneously (SC). |
|
| LY3437943 (Severe Hepatic Impairment) | Experimental | LY3437943 administered SC. |
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| LY3437943 (Moderate Hepatic Impairment) | Experimental | LY3437943 administered SC. |
|
| LY3437943 (Mild Hepatic Impairment) | Experimental | LY3437943 administered SC. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LY3437943 | Drug | Administered SC. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics (PK): Area under the concentration versus time curve from time zero to infinity (AUC0-∞) of LY3437943 | PK: AUC0-∞ of LY3437943 | Predose up to 30 days postdose |
| PK: Maximum observed concentration (Cmax) of LY3437943 | PK: Cmax of LY3437943 | Predose up to 30 days postdose |
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Inclusion Criteria:
All Participants:
Exclusion Criteria:
Participants with hepatic impairment:
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| Name | Affiliation | Role |
|---|---|---|
| Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) | Eli Lilly and Company | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Arizona Clinical Trials - Chandler | Chandler | Arizona | 85225 | United States | ||
| Accel Research Sites- Clinical Research Unit |
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| ID | Term |
|---|---|
| D048550 | Hepatic Insufficiency |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| C000729679 | retatrutide |
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| DeLand |
| Florida |
| 32720 |
| United States |
| Advanced Pharma Clinical Research | Miami | Florida | 33147-4040 | United States |
| American Research Corporation at Texas Liver Institute | San Antonio | Texas | 78215 | United States |
| Pinnacle Clinical Research | San Antonio | Texas | 78229 | United States |