FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort

HÉRITABILITÉ FAMILIALE, INTERACTIONS GÈNE-GÈNE ET GÈNE-ENVIRONNEMENT DANS LE DOMAINE DES MALADIES CARDIOVASCULAIRES ET RENALES. Cinquième Visite de la Cohorte STANISLAS

The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.

The main objective of the STANISLAS cohort is to identify the factors associated with cardiovascular aging (assessed through the study of the degradation of morphological and functional parameters of the heart and vascular systems).

Data (clinical, biological, morphological, genetic and lifestyle) from previous visits (the first having been initiated in the mid-1990s) will be considered as exposure and / or adjustment variables.

The exposure variables of interest will be:

• The components of metabolic syndrome (MS),
• Genetic determinants, through an approach of family segregation and candidate genes,
• Multi-omic biomarkers analyzed from the biological collection of the first assessments of the cohort
• Food intake, nutrition and eating behavior

The secondary objectives are

• Identify the factors associated with a degradation of renal parameters (renal function and proteinuria).
• Identify the factors associated with a degradation of metabolic parameters.
• To assess the association between SARS-CoV-2 infection (questionnaire and serological approach) and cardiovascular and renal parameters
• Identify factors associated with the occurrence of clinical cardiovascular events.
• Association between Covid 19 events and general disabling symptoms
• Complete the cohort's biological collection for future biomarker assays related to previous objectives

Inclusion Criteria:

• aged over 18
• Person who participated in the Stanislas Cohort
• Person affiliated to a social security scheme or beneficiary of such a scheme
• Person having received complete information on the organization of the research and having signed an informed consent

Exclusion Criteria:

• Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric treatment under Articles L. 3212-1 and L. 3213-1

• Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code:

  • Pregnant woman, parturient or nursing mother
  • Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
  • Person of full age unable to express consent