This study intends to carry out pain neuroscience education intervention for TKA patients to clarify the effect of this method on the degree of postoperative pain, the incidence of pain catastrophizing, kinesiophobia, and knee joint function rehabilitation in TKA patients, so as to provide a basis for clinical nursing of such patients.

Inclusion Criteria:

1. Patients diagnosed as KOA according to the criteria and undergoing unilateral total knee arthroplasty for the first time;
2. The subjects included in this study were men or women aged 45-74 years;
3. Clear self-cognition, can browse the text by themselves or can answer questions correctly;
4. Those who voluntarily participated in the study and signed an informed consent form after understanding the relevant information of the study;
5. Without serious physical diseases such as heart, liver or kidney;
6. No history of mental illness or drug dependence.

Exclusion Criteria:

1. Combined with severe trauma in other parts;
2. Accompanied by serious damage to other organs, such as heart and cerebrovascular diseases, lung and kidney diseases;
3. Patients with knee tumor and severe knee deformity who could not complete the rehabilitation;
4. With neurological diseases that limit physical activity;
5. Participating in other investigators during the same period.