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The purpose of this study is to assess the outcomes and efficacy of ejaculatory preserving TURP in terms of voiding, erectile function, and ejaculation.
The prostatic gland plays a central role in andrology. It is involved both in fertility and in sexuality with a major role in ejaculation and possibly in orgasm. This could explain the association between the andrological symptoms and prostatic disorders.
The prevalence of Benign Prostatic Hyperplasia (BPH) is approximately 50% for men in their fifties and reaches up to 80% for men over 80 years of age, representing one of the most common diseases affecting males, with potentially significant impact on their quality of life.
It is estimated that around half of men suffering severe or medical treatment unresponsive lower urinary tract symptoms (LUTS) will be offered a surgical procedure to relieve benign prostatic obstruction (BPO).
Despite continuing development of new minimally invasive surgical methods, transurethral resection of the prostate (TURP) still remains the gold standard surgical treatment for LUTS due to BPH.
Although it is benign, this disease has been shown to have a negative impact on the patient's health-related quality of life (HRQL), marked by obstructive and irritative LUTS.
As BPH in most cases is not a life-threatening condition, the main outcomes of its treatment are not only the improvement in LUTS and functional parameters but also quality of life after surgery.
Whilst efficacy of the conventional TURP is proven, a common potentially bothersome side effect, the retrograde ejaculation (RE) which occurs in 65-90% of patients undergoing TURP.
It has been reported that ablative techniques like TURP and recent laser procedures including holmium, thulium and greenlight cause similar rates of ejaculatory dysfunction, occurring in almost three out of four to five men.
For decades, men have been counseled to expect dry orgasm after TURP because of the retrograde flow of semen as a result of bladder neck disruption.
Erectile dysfunction and Ejaculatory dysfunction (EjD) can have a substantial deleterious effect on the Quality of life (QoL) of men who have previously maintained regular sexual activity, inducing significantly increased levels of anxiety and depression.
More recently, a better understanding of ejaculation physiology has enabled the emergence of modified surgical techniques with the aim of preserving antegrade ejaculation.
The key point of standard TURP is resecting the tissues enveloped in the prostatic capsule and the bladder neck, while protecting the urethral tissues below the verumontanum.
The bladder neck plays a significant role in reproduction. For men, bladder neck closure facilitates anterograde ejaculation. It actively contracts the bladder neck during ejaculation through a rich noradrenergic innervation by sympathetic nerves.
Vernet et al. showed that contraction of the bladder neck was not important for anterograde ejaculation. Using endorectal ultrasound videos performed during masturbation in 30 men, it was possible to visualize the bladder neck, the prostate, and the bulbar urethra during ejaculation. They observed that during ejaculation, the verumontanum underwent a slight caudal shift, momentarily making contact with the opposite urethral wall and sperm emitted from the ejaculatory ducts was directed distally by contractions of the external sphincter coordinated with contractions of the bulbar urethra, thus demonstrating the importance of the muscular tissue around the verumontanum and particularly its proximal part. They described this area as a "high-pressure ejaculatory area". The closure of the bladder neck did not seem to play a role in this mechanism. As a result, one can conclude that as long as the tissues around the verumontanum are not injured, ejaculation should still occur even with a well-open bladder neck.
Recently, together with a better understanding of the mechanisms of ejaculation, a greater importance has been given to the impact of dry ejaculation on patients' QoL. A balance between symptomatic improvement in LUTS and preservation of sexual function needs to be addressed for men seeking surgical treatment.
Modifications based on Supramontanal sparing hypothesis have reported favorable outcomes to as high as 92%.
Although preservation of bladder neck structures is often associated with preservation of antegrade ejaculation, the current modern approach is the preservation of the precollicular and para-collicular tissue in the area where the ejaculatory ducts emerge near the verumontanum in the distal apical tissue in laser, aquablation, and bipolar electrosurgical prostatectomy techniques.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Active Comparator |
| |
| Group 2 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ejaculatory Preserving Transurethral resection of prostate | Procedure | Transurethral resection of prostate with preservation of 1cm safety area above verumontanum and without paracollicular digging |
| Measure | Description | Time Frame |
|---|---|---|
| Preservation of Ejaculation | The number of patients who can ejaculate after TURP | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum Flow Rate (Qmax) | The maximum flow of urine measured by Uroflowmetry | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University | Sohag | Sohag Governorate | Egypt |
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In this study, 103 patients were assessed for eligibility; 8 patients did not meet the criteria and 5 patients refused to participate in the study. The remaining patients were randomly allocated into two equal groups (45 patients in each). All allocated patients were followed-up and analyzed statistically.
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| ID | Title | Description |
|---|---|---|
| FG000 | Group 1 | Ejaculatory Preserving Transurethral resection of prostate: Transurethral resection of prostate with preservation of 1cm safety area above verumontanum and without paracollicular digging |
| FG001 | Group 2 | Standard Transurethral Resection of prostate: Transurethral resection of prostate including whole adenoma till the capsule. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Group 1 | Ejaculatory Preserving Transurethral resection of prostate: Transurethral resection of prostate with preservation of 1cm safety area above verumontanum and without paracollicular digging |
| BG001 | Group 2 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Preservation of Ejaculation | The number of patients who can ejaculate after TURP | Posted | Count of Participants | Participants | 6 months |
|
|
6 months
TURP is an elective surgery that the patient is prepared with full lab and surgical fitness in preoperative assessment furthermore, TURP has a high safety profile that all adverse events rarely lead to mortality
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Group 1 | Ejaculatory Preserving Transurethral resection of prostate: Transurethral resection of prostate with preservation of 1cm safety area above verumontanum and without paracollicular digging |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| intraperitoneal bladder perforation | Renal and urinary disorders | Systematic Assessment |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| sever irritative LUTS | Renal and urinary disorders | Systematic Assessment |
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Sabri mahmoud | faculty of medicine sohag university | 201061691091 | sabriahmed188@gmail.com |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jun 14, 2024 | Oct 14, 2025 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D000097910 | Ejaculatory Dysfunction |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D012735 | Sexual Dysfunction, Physiological |
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|
| Standard Transurethral Resection of prostate | Procedure | Transurethral resection of prostate including whole adenoma till the capsule. |
|
|
Standard Transurethral Resection of prostate: Transurethral resection of prostate including whole adenoma till the capsule.
| BG002 | Total | Total of all reporting groups |
| years |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
| Maximum Flow Rate (Qmax) | The maximum flow of urine measured by uroflowmetry | Mean | Standard Deviation | ml/sec |
|
| Sex: Female, Male | Count of Participants | Participants |
|
|
| Secondary | Maximum Flow Rate (Qmax) | The maximum flow of urine measured by Uroflowmetry | Posted | Mean | Standard Deviation | ml/sec | 6 months |
|
|
|
| 0 |
| 45 |
| 0 |
| 45 |
| 12 |
| 45 |
| EG001 | Group 2 | Standard Transurethral Resection of prostate: Transurethral resection of prostate including whole adenoma till the capsule. | 0 | 45 | 1 | 45 | 23 | 45 |
| Minor Capsular perforation | Renal and urinary disorders | Systematic Assessment |
|
| Blood transfusion | Blood and lymphatic system disorders | Systematic Assessment |
|
| Clot retention | Renal and urinary disorders | Systematic Assessment |
|
| Stress incontinence | Renal and urinary disorders | Systematic Assessment |
|
| Bladder neck contracture | Renal and urinary disorders | Systematic Assessment |
|
| Stricture bulbar urethra | Renal and urinary disorders | Systematic Assessment |
|
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| D052801 | Male Urogenital Diseases |