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The purpose of this prospective randomized controlled trial is to determine whether using the Oxygen Reserve Index can prevent hyperoxemia in pediatric patients receiving single-lung ventilation.
Participants will have their FiO2 adjusted in a prescribed manner based on the arm to which they are assigned.
The researchers will compare whether blood oxygen levels were lower in the ORI group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional arm | No Intervention | Moderate hyperoxia as determined by T1 arterial blood gas. For moderate hyperoxemia (PaO2 > 300 mmHg), reduce the inspired oxygen concentration to 80% and for severe hyperoxemia to 70%. In the situation of hypoxia, where the peripheral oxygen saturation decreases to less than 95% even in 100% of FiO2, the following treatment is indicated: Fluid administration, inotropes administration (dopamine), alveolar recruitment, return to two-lung ventilation, and application of continuous positive airway pressure. | |
| ORI arm | Experimental | Target ORiâ„¢ of 0.15, check the ORiâ„¢ every 5 minutes and adjust the inspired oxygen concentration in 5% increments. If the ORiâ„¢ decreases to less than 0.15, treat it in the same way as if hypoxia occurred in the conventional group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Titration of FiO2 | Procedure | The inhaled oxygen concentration after one-lung ventilation will be treated by the group. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of moderate to severe hyperoxemia in arterial blood gas analysis at T2 (30 minutes after one lung ventilation) | arterial oxygen content over 200 | 30 minutes after initiation of one-lung ventilation |
| Measure | Description | Time Frame |
|---|---|---|
| average Oxygen Reserve Index value | during one lung ventilation | |
| time-weighted average inspired oxygen fraction | during one lung ventilation | |
| incidence of hypoxemia |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | Seoul | 03080 | South Korea |
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| perioperative period |
| incidence of perioperative complications | perioperative period |