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Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
These 3 inflammatory cardiac diseases have clinical, biological, and echographic similarities and differences. Nevertheless their modalities of monitoring, management and evolution are different. The investigators wish to retrospectively analyze biological and echocardiographic data of Kawasaki disease, myocarditis, PIMS patients managed at Nancy Children Hospital from January 1, 2017 to June 31, 2023.
The primary objective of this study is to identify, for these 3 pathologies, the prognostic factors of initiation of inotropic support.
The secondary objective is to identify the prognostic factors of degradation of ventricular function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MYOCARDITIS | No intervention Study of available clinical, biological, and echocardiographic data |
| |
| KAWASAKI | No intervention Study of available clinical, biological, and echocardiographic data |
| |
| PIMS | No intervention Study of available clinical, biological, and echocardiographic data |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| study of biological samples and echocardiographic data and link with need of hemodynamic support | Other | observational study : there is no intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| need of hemodynamic support | The need for haemodynamic support is defined dichotomously: yes or no. The investigators wish to identify the predictive factors of need for haemodynamic support among the following variables: groups (PIMS, KAWASAKI, MYOCARDITIS), cardiac biomarkers (troponin and NT-pro-BNP at admission (in ng/ml)) and echocardiographic criterias (Left Ventricular Ejection fraction, global and regional longitudinal strain at admission (in %)). | up to 20 days |
| Measure | Description | Time Frame |
|---|---|---|
| deterioration of Left Ventricular Ejection fraction | Left Ventricular Ejection fraction degradation is defined as an Left Ventricular Ejection fraction below the value of the first quartile of Left Ventricular Ejection fraction of all patients taken into account (Left Ventricular Ejection fraction as a percentage). The investigators wish to identify the predictive factors of Left Ventricular Ejection fraction degradation among the following variables: groups (PIMS, KAWASAKI, MYOCARDITIS), cardiac biomarkers (troponin and NT-pro-BNP at admission (in ng/ml)) and echocardiographic criterias (Left Ventricular Ejection fraction , global and regional longitudinal strain at admission (in %)). |
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Inclusion Criteria:
Exclusion Criteria:
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age < 18 years initial management and follow up in Nancy university children hospital center for PIMS Myocarditis and Kawasaki disease patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aurelien Capogna | Contact | +33603566308 | a.capogna@chru-nancy.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gilles BOSSER | Vandœuvre-lès-Nancy | 54511 | France |
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| up to 20 days |
| ID | Term |
|---|---|
| D009205 | Myocarditis |
| C000705967 | pediatric multisystem inflammatory disease, COVID-19 related |
| D009080 | Mucocutaneous Lymph Node Syndrome |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014657 | Vasculitis |
| D014652 | Vascular Diseases |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D017445 | Skin Diseases, Vascular |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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