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| ID | Type | Description | Link |
|---|---|---|---|
| 1UG3NS130228-01 | U.S. NIH Grant/Contract | View source | |
| 2000031893 | Other Identifier | Advarra IRB |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
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CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial [a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAPTIVA-MRI Group | CAPTIVA patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Other | Additional MRI to the CAPTIVA study at baseline and 12 months follow-up |
|
| Measure | Description | Time Frame |
|---|---|---|
| Establish ICAS hemodynamic and plaque MRI biomarkers as reliable predictors of recurrent ischemic stroke in the vascular territory of the index stroke. | Recurrent ischemic stroke, defined as symptomatic infarct in the vascular territory of the index stroke artery. This outcome is centrally adjudicated in CAPTIVA using an American Heart Association definition of ischemic stroke | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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ICAS patients who have a recent stroke and was enrolled into CAPTIVA.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ka-Ho Wong | Contact | 801-585-7575 | ka-ho.wong@hsc.utah.edu | |
| Amy Sulken | Contact | sulkenay@ucmail.uc.edu |
| Name | Affiliation | Role |
|---|---|---|
| David Liebeskind, MD | University of California, Los Angeles | Principal Investigator |
| Sepideh Amin-Hanjani, MD | University Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama Hospital | Recruiting | Birmingham | Alabama | 35233 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19807851 | Result | Suri MF, Johnston SC. Epidemiology of intracranial stenosis. J Neuroimaging. 2009 Oct;19 Suppl 1:11S-6S. doi: 10.1111/j.1552-6569.2009.00415.x. | |
| 24135208 | Result | Holmstedt CA, Turan TN, Chimowitz MI. Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment. Lancet Neurol. 2013 Nov;12(11):1106-14. doi: 10.1016/S1474-4422(13)70195-9. |
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| Rano Chatterjee, MD |
| Washington University School of Medicine |
| Principal Investigator |
| Adam de Havenon, MD, MS | Yale University | Principal Investigator |
| Yale New Haven Hospital | Not yet recruiting | New Haven | Connecticut | 06510 | United States |
|
| MedStar Washington Hospital Center | Not yet recruiting | Washington D.C. | District of Columbia | 20010 | United States |
|
| Baptist Medical Center Jacksonville | Recruiting | Jacksonville | Florida | 32207 | United States |
|
| Jackson Memorial Hospital, Miami | Recruiting | Miami | Florida | 33136 | United States |
|
| SIH Memorial Hospital of Carbondale | Not yet recruiting | Carbondale | Illinois | 62901 | United States |
|
| University of Illinois Hospital | Recruiting | Chicago | Illinois | 60612 | United States |
|
| University of Chicago Medical Center | Recruiting | Chicago | Illinois | 60637 | United States |
|
| Barnes Jewish Hospital | Recruiting | St Louis | Missouri | 63108 | United States |
|
| Buffalo General Medical Center | Recruiting | Buffalo | New York | 14203 | United States |
|
| North Shore University Hospita | Recruiting | Manhasset | New York | 11030 | United States |
|
| Carolinas Medical Center | Not yet recruiting | Charlotte | North Carolina | 28203 | United States |
|
| UH Cleveland Medical Center | Recruiting | Cleveland | Ohio | 44106 | United States |
|
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
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