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Nonalcoholic steatohepatitis (NASH) is the most common cause of chronic liver disease in Western countries and one of the leading causes of liver transplantation in the world. Its spectrum ranges from simple steatosis to decompensated cirrhosis, resulting from progressive fibrosis due to inflammation and cellular injury. The reasons why patients with the same degree of steatosis have different evolutions are not sufficiently known. The objective of this project is to identify biomarkers that predict disease progression, using omics techniques, which can serve to develop new therapeutic strategies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Steatosis | Patients with non-alcoholic fatty liver disease presenting exclusively with steatosis, without fibrosis or inflammation | ||
| Steatohepatitis | Patients with non-alcoholic fatty liver disease presenting with steatosis and degree >1 of liver fibrosis |
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| Measure | Description | Time Frame |
|---|---|---|
| Steatosis, without fibrosis or inflammation | Patients with non-alcoholic fatty liver disease presenting exclusively with steatosis, without fibrosis or inflammation | 12 months |
| Steatohepatitis, with fibrosis | Patients with non-alcoholic fatty liver disease presenting with steatosis and degree >1 of liver fibrosis | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Quaternary university hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guilherme FM Rezende, MD PhD | Contact | 55+21999976292 | guimottarezende@gmail.com | |
| Regina CS Goldenberg, BSND PhD | Contact | 55+21999913066 | rcoeli@biof.ufrj.br |
| Name | Affiliation | Role |
|---|---|---|
| Guilherme FM Rezende, MD PhD | Universidade Federal do Rio de Janeiro | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal University of Rio de Janeiro | Rio de Janeiro | Rio de Janeiro | 21941-630 | Brazil |
There is not a plan to make individual participant data available.
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
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| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |