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A multicenter, non-randomized prospective longitudinal study to evaluate the feasibility of Tricog's Remote platform for Guideline Directed Medical Therapy (GDMT) titration and remote patient monitoring among patients with Heart Failure.
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| Measure | Description | Time Frame |
|---|---|---|
| NT-ProBNP | Serum level of N-terminal pro B-type natriuretic peptide | Baseline, week 2, 1-month follow-up, week 8, 3-month follow-up, week 16, week 20, 6-month follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| HF Hospitalizations | Hospitalizations for heart failure | 3-month, and 6-month follow-up |
| 6-min walk distance | Six-minute walk test distance in meters |
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Inclusion Criteria:
Exclusion Criteria:
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Adults hospitalized for decompensated heart failure or in the post-discharge period following a heart failure hospitalization will be eligible for enrollment. Participants that meet eligibility criteria will be enrolled consecutively.
Heart Failure with preserved ejection Fraction (HFpEF) will be defined by EF ≥ 50% at the time of HF diagnosis. Heart Failure with reduced ejection fraction (HFrEF) will be defined by EF <40%, and patients with EF between 40-49% will be identified as Heart Failure with mildly reduced EF (HFmrEF).
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University Medical Center | Durham | North Carolina | 27710 | United States | ||
| UT Southwestern Medical Center |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Baseline, 1-month follow-up, 3-month, and 6-month follow-up |
| KCCQ Overall Summary Score | The KCCQ summary score ranges from 0 to 100, where higher scores indicate better quality of life. | The survey will be assessed at baseline, 1-month, 3-month, and 6-month follow-up. |
| Atrial Fibrillation Anticoagulation Utilization | Percentage of participants with atrial fibrillation indicated for anticoagulation that are on systemic anticoagulation. | Baseline, 3-month, and 6-month |
| HFpEF Medication Utilization | Percentage of participants on all three classes (ACEi/ARB/ARNI or MRA or SGLT2i) | Baseline, 1-month follow-up, 3-month, and 6-month follow-up |
| composite modified HF Collaboratory GDMT score | 2 points for optimal dosing of each medication class (beta-blockers, ACEi/ARB/ARNI, MRA, SGLT2i) and 1 point for suboptimal beta-blocker or ACEi/ARB dosing, expressed as a percentage of maximum possible points. | Baseline, 1-month follow-up, 3-month, and 6-month follow-up |
| Changes in Diuretic Dose | The number of days on higher than baseline dose of diuretic | 3-month, 6-month |
| Dallas |
| Texas |
| 75390 |
| United States |
| Manipal Hospital | Bengaluru | Karnataka | 560017 | India |
| Sakra World Hospital | Bengaluru | Karnataka | 560103 | India |