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The goal is to test feasibility of a frailty intervention, including exercises and nutritional supplementation.
The frailty intervention includes frequent short exercise sessions incorporating balance, resistance training, and walking to accommodate diminished endurance, with synergistic protein and nutritional supplementation, delivered on top of usual care in the post-acute Skilled Nursing Facility (SNF) setting. There is no control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Regular exercise sessions incorporating balance, resistance training, and walking to accommodate diminished endurance, with synergistic protein and nutritional supplementation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multicomponent (Exercise + Protein Supplementation) | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of the Intervention | Feasibility will be determined by assessing 1) the proportion of eligible patients enrolled, and 2) the proportion of participants adherent to the intervention Range: 0-100% (higher values indicate higher feasibility). | Estimated average <1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Gait Speed | Walking speed measured in m/s | Discharge (on average between 2-3 weeks) |
| Grip Strength | Dominant Hand Grip Strength measured in Kg (higher values indicate better performance) |
| Measure | Description | Time Frame |
|---|---|---|
| Length of stay | Length of admission to SNF | Entire study period (on average over 2-3 weeks) |
| Hospital readmission | Proportion of participants who are readmitted to the hospital during SNF stay |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sandra Shi, MD MPH | Hebrew SeniorLife | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hebrew Rehabilitation Center | Boston | Massachusetts | 02131 | United States |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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|
| Discharge (on average at 2-3 weeks) |
| The Patient Reported Outcomes Measurement Information System (PROMIS Global Health v1.2) | The PROMIS Scale v1.2 - Global Health (also referred to as PROMIS-10) is a ten-item patient reported measure of physical, mental and social health. Items query general health, quality of life, physical health, mental health, satisfaction with discretionary social activities, carrying out every day physical activities, pain, fatigue, satisfaction with social roles, and emotional problems (Hays et al., 2009). Physical Health (physical health, physical function, pain, and fatigue items) and Mental Health (quality of life, mental health, satisfaction with discretionary social activities, and emotional problem items) (Hays et al., 2009). T scores for both Physical and Mental Health scales. | Discharge (on average at 2-3 weeks) |
| Modified Barthel Index | Assessment of functional disability based on 10 activities of daily life (ADLs). Range 0-10 with high values indicating better performance. | Discharge (on average at 2-3 weeks) |
| Adherence to exercise | Proportion of sessions with exercise during the intervention period Range: 0-100% (higher values indicate better adherence) | Entire study period (on average over 2-3 weeks) |
| Adherence to supplementation | Proportion of oral nutritional supplement consumed over the total number of supplements during the intervention period per self-report Range: 0-100% (higher values indicate better adherence) | Entire study period (on average over 2-3 weeks) |
| Entire study period (on average over 2-3 weeks) |
| Community Discharge | Proportion of participants who are discharged to the community from SNF stay | Entire study period (on average over 2-3 weeks) |
| Falls | Proportion of participants who experience a fall, as documented in the medical record, during SNF stay | Entire study period (on average over 2-3 weeks) |